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Accurate quantitative bioanalysis using LC-MS/MS is challenging due to matrix effects, but using internal standards and new methods like in-sample calibration could improve results.

Method detects finasteride in plasma at very low concentrations.

Finasteride and analogues separated using LC-MS-MS technique.

The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.

A new method was developed to accurately detect and measure 47 different drug ingredients in various products.

Women with female-pattern baldness produce more testosterone, but 5a-reductase inhibition treatment won't help.

Matrix effects in LC-MS can be managed but not completely avoided.

The conclusion is that recognizing hair growth cycles can improve the precision of dietary and health assessments from hair analysis.

L-PGDS has specific binding sites for its functions and could help in drug delivery system design.

Human skin cells have a high-affinity system for biotin transport, crucial for skin health.

High DHA levels delay wound healing and worsen skin repair quality.

Finasteride effectively blocks enzyme causing male pattern baldness.

The research explains how a human enzyme binds and processes its substrate, which could relate to its role in biological functions and hair loss.

MT-DADMe-ImmA can selectively kill head and neck cancer cells without harming normal cells.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Glutamine metabolism affects hair stem cell maintenance and their ability to change back to stem cells.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

Some Chrysanthemum samples from the USA, Europe, and China differ in quality and some contain harmful cadmium.

Decursin shows promise for treating cancer, neuroprotection, inflammation, and hair loss.

Addressing underrepresentation in Parkinson's research is crucial for better treatments and understanding.

Air Vice-Marshal Sir Ralph Jackson significantly advanced dialysis technology in the UK.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Plant sterols have health benefits like lowering cholesterol, but more research is needed to understand their effects and improve their extraction and sustainability.

Researchers found a specific immune receptor in patients that causes severe skin reactions to a drug.

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Researchers found a way to create cells from stem cells that act like human cells important for hair growth and could be used for hair regeneration treatments.

Alcohol in teen years leads to more adult drinking, finasteride doesn't help.

Androgen therapy can help with symptoms like low libido in women, but more research is needed to understand its long-term safety and effects on health.

Scientists found a new, less invasive way to get stem cells from horse hair for veterinary medicine.