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SPRY1 deficiency in skin cells causes stem cells to move to the skin surface, leading to increased pigmentation.

In a mouse model of chemotherapy-induced alopecia, this study found that inhibiting the protein S100A8 with paquinimod alleviated hair loss and reduced oxidative stress and ferroptosis, suggesting a potential therapeutic strategy for managing this side effect in chemotherapy patients.

In this study, a novel liposomal peptide formulation significantly enhanced hair growth in mice compared to minoxidil, but results on human tissue penetration were inconclusive, suggesting further research is needed for translation to human use.

This research explores developing liposomal formulations to enhance the delivery of difficult-to-absorb agents directly to hair follicles and sebaceous glands, with minoxidil and plasmid DNA as study molecules.

In this study, researchers found that deficiencies in Gsdma1/2/3 significantly inhibited the initiation and progression of cutaneous squamous cell carcinoma (cSCC) in mice, suggesting GSDMA's role in promoting cSCC proliferation and its potential as a therapeutic target.

This study found that hamster sebaceous glands have high affinity binding sites for dihydrotestosterone, with competition from other steroids indicating specific binding characteristics.

This study found that synthetic ceramide shampoo improved dandruff and erythema while reducing water loss when compared to control in a group of 20 subjects over four weeks.

This study found that mice lacking syndecan-1 experienced cold stress and metabolic issues due to reduced intradermal fat, which was restored by thermoneutral housing or rosiglitazone treatment.

This study found that sebaceous glands can regenerate after PPARg deletion in adult skin, relying on the hair cycle and FGFR signaling.

In an animal model, this study found that PEG hydrogels delivering M2 macrophage-derived exosomes effectively promoted M1 to M2 macrophage transition and enhanced wound healing.

This study provides conclusive evidence of exogenous calcium fatty acid deposits forming between the cuticle layers in hair, affecting its optical and mechanical properties.

This study demonstrates that human skin is capable of steroid hormone synthesis, but its role in androgenic skin disorders like acne and alopecia is yet to be clarified.

In this study, a mouse model with a PIK3CA gain-of-function mutation in Schwann cells revealed unique communication with neighboring cells and a glycolytic shift in peripheral nerves, and early alpelisib treatment significantly improved symptoms, though efficacy declined with delayed administration due to limited drug penetration.

This study developed a multifunctional TA-MoS2-SF hydrogel for diabetic ulcer treatment, demonstrating enhanced photothermal bactericidal effects, immune environment remodeling, and fibroblast proliferation, suggesting it may serve as an effective 'antibacterial-immunomodulatory-repair' strategy.

This study found that aligned electrospinning membranes enhance skin wound healing by upregulating MMP12 expression and inhibiting fibroblast migration, which results in reduced scar formation, providing valuable insights for developing more effective biological dressings.

This study reported that mSKPs and DMSCs share similarities in biological characteristics but exhibit distinct transcriptome profiles, with mSKPs being more immune-related and DMSCs more associated with differentiation and disease pathways.

This study found that stem cell factor combined with fibronectin and type IV collagen promotes migration of amelanotic melanocytes, which may help explain their movement during vitiligo repigmentation.

This study found that in a shaving animal model of mice, increased enzyme activities and gene expression correlated with enhanced hair growth, suggesting they are good biomarkers in the anagen phase.

This case report describes a unique instance of a 6-year-old girl developing angioedema after treatment with squaric acid dibutylester for alopecia areata.

This case report describes a twenty-year-old woman misdiagnosed with a sebaceous cyst that was actually pilomatrixoma, a benign skin lesion from hair matrix cells, confirmed by histopathology after excision.

This study found that ALKBH5 plays a critical role in wound re-epithelialization by enhancing the stability of PELI2 mRNA, and its absence delays wound healing. Supplementation with PELI2 can partially rescue this delay, pointing to potential new therapies for stubborn wounds.

This study developed lipid-core nanocapsules for encapsulating menthol, improving its solubility and thermal stability, and demonstrated their safety and rapid skin absorption in ex vivo tests, highlighting potential applications for cosmeceuticals.

This study identified a distinct CD49fhigh mesenchymal stem cell subpopulation in the dermis that supports hair follicle development and maintenance via Notch signaling activation.

This study proposed the existence of a membrane-like structure between the cuticle and cortex in human hair, which may provide strong protection against external stimuli.

This case report describes a 5-year-old girl with lipoid proteinosis, characterized by a raspy voice, thinning scalp hair, and recurrent crusted lesions leading to pock-like scars.

This review highlights the potential of mesenchymal stem cell secretome for developing topical treatments aimed at skin regeneration and treating various diseases, but notes a lack of studies on safety, efficacy, and standardization processes for its clinical use.

This study found that Finasteride may spontaneously diffuse into an SDS-based model cell membrane at a significant rate, with distinct behavior in polar and non-polar solutions.

This study found that the retinol dehydrogenases SDR16C5 and SDR16C6 in mice play a crucial role in skin retinol dehydrogenase activity, affecting hair growth and gland functions without impacting survival.

This study proposes the miR-22-5p-LEF1 axis as a novel pathway that may regulate hair follicle stem cell proliferation.

This study found that basal cell carcinoma is more prevalent on the cutaneous lip while squamous cell carcinoma is more common on the vermilion lip, with rare recurrences following Mohs micrographic surgery.