Androgen Binding to Cytosol and Nuclei of Hamster Sebaceous Glands

    February 1978 in “ Journal of steroid biochemistry/Journal of Steroid Biochemistry ”
    S. Takayasu
    TLDR Dihydrotestosterone specifically binds to hamster sebaceous glands, with a higher affinity than testosterone.
    The study demonstrated specific dihydrotestosterone (DHT) binding in the cytosol and nuclei of hamster sebaceous glands. In the cytosol, a high-affinity binding peak for DHT was observed at the 7–8S region, with a dissociation constant (KD) of 1.5 × 10−9 M. Testosterone also bound in this region but to a lesser extent. Various steroids competed for binding, with DHT showing the highest affinity. In the nuclei, three peaks of radioactivity were observed, with the second peak indicating specific DHT binding, which was saturable and could be inhibited by excess unlabeled DHT and cyproterone acetate. The formation of the DHT-macromolecule complex in the nuclei required cytoplasmic factors.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 134 results

      community Why is it that low testosterone causes hair loss as well? How can I be balding?

      in Chat  158 upvotes 8 months ago
      The conversation discusses the confusion over low testosterone potentially causing hair loss, with users sharing personal experiences and knowledge about hair loss treatments like Finasteride. Some users suggest that hair follicle sensitivity to DHT, not testosterone levels, is the key factor in balding, and others discuss the side effects of hair loss medications.

      community Saying creatine causes loss on fin/dut makes no sense and this is why

      in Finasteride/Dutasteride  42 upvotes 10 months ago
      The conversation discusses whether creatine causes hair loss for those using finasteride or dutasteride, with some suggesting creatine might increase DHT or upregulate androgen receptors, potentially leading to hair loss. Others argue the evidence is not conclusive, citing limited studies and personal anecdotes, with some avoiding creatine as a precaution.

      community Please take a vitamin & hormone test

      in Chat  256 upvotes 1 week ago
      Checking vitamin and hormone levels is important for addressing hair loss, as deficiencies in vitamin D, zinc, and iron can affect hair growth. Treatments like finasteride, minoxidil, and vitamin supplements are used, but addressing deficiencies is crucial for effectiveness.

      community Why is dht bad for scalp hair but good for hair on the rest of body?

      in Satire  109 upvotes 1 year ago
      The conversation discusses why DHT (dihydrotestosterone) negatively affects scalp hair but promotes growth elsewhere on the body. Various opinions include genetic predispositions, differences in hair follicle reactions to DHT, and the potential role of Omega-3 in reducing inflammation and promoting hair health.

    Related Research

    1 / 1 results