Androgen Binding to Cytosol and Nuclei of Hamster Sebaceous Glands

February 1978 in “ Journal of steroid biochemistry/Journal of Steroid Biochemistry ”

S. Takayasu

dihydrotestosterone DHT testosterone cytoplasmic factors cytosol nuclei sebaceous glands cyproterone acetate DHT testosterone cytoplasm cytoplasmic factors sebaceous glands cyproterone acetate

TLDR Dihydrotestosterone specifically binds to hamster sebaceous glands, with a higher affinity than testosterone.

The study demonstrated specific dihydrotestosterone (DHT) binding in the cytosol and nuclei of hamster sebaceous glands. In the cytosol, a high-affinity binding peak for DHT was observed at the 7–8S region, with a dissociation constant (KD) of 1.5 × 10−9 M. Testosterone also bound in this region but to a lesser extent. Various steroids competed for binding, with DHT showing the highest affinity. In the nuclei, three peaks of radioactivity were observed, with the second peak indicating specific DHT binding, which was saturable and could be inhibited by excess unlabeled DHT and cyproterone acetate. The formation of the DHT-macromolecule complex in the nuclei required cytoplasmic factors.

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research Metabolism of Androgens by Isolated Human Beard Hair Follicles

31 citations, October 1971 in “Steroids”

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