Metabolism of Androgens by Isolated Human Beard Hair Follicles

October 1971 in “ Steroids ”

Á Fazekas, André Lanthier

testosterone androstenedione dehydroepiandrosterone 5α-androstanedione 5α-dihydrotestosterone androsterone 5-androstene-3β,17β-diol 7α-hydroxy-dehydroepiandrosterone DHEA DHT

TLDR Human beard hair follicles change testosterone into other related hormones, but don't much change androstenedione into testosterone.

In a study from 1971, isolated human beard hair follicles were exposed to various androgens, including testosterone, androstenedione, and dehydroepiandrosterone, to observe their metabolism. The results showed that testosterone was primarily metabolized into androstenedione, 5α-androstanedione, 5α-dihydrotestosterone, and androsterone. The conversion of androstenedione to testosterone and 5α-dihydrotestosterone was found to be minimal. Dehydroepiandrosterone was metabolized into 5-androstene-3β,17β-diol, 7α-hydroxy-dehydroepiandrosterone, and androstenedione at rates higher than those previously reported for human skin. The study discussed the implications of these metabolic processes in relation to the action mechanism of androgens.

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research Metabolism of Androgens by Isolated Human Beard Hair Follicles

31 citations, October 1971 in “Steroids”

Human beard hair follicles change testosterone into other related hormones, but don't much change androstenedione into testosterone.