Determination of Free Chemical Potential for Finasteride Diffusion Through SDS Micelle Suggested as Alternative Living Membrane System
August 2022
in “
International journal of membrane science and technology
”
TLDR Finasteride diffuses spontaneously through SDS micelles, suggesting they can replace living cell membranes.
The study investigated the diffusion of Finasteride through a sodium dodecyl sulfate (SDS) micelle, proposed as an alternative to living cell membranes. Using spectroscopic methods, the diffusion was analyzed in both polar (buffer phosphate solution, pH 7.4) and non-polar (cyclohexane) environments. Results showed that Finasteride in the polar solution had a stable absorption peak at 253 nm, while the non-polar medium had a lower attenuation coefficient and shorter maximum wavelength. The chemical potential for Finasteride diffusion was determined to be -6294.76 J mol-1, indicating a spontaneous process, with a diffusion rate constant of 51.11 min-1 and an equilibrium constant of 11.5.
