Enzyme Activity and Gene Expression Changes Related to Hair Growth in C57BL/6 Mice
January 2008
in “
한국미용학회지
”
C57BL/6 mice enzyme activities gene expression hair growth shaving animal model normal group saline vehicle control jojoba oil positive control 3% minoxidil experimental group 3% mixture oil of peppermint and rosemary ALP γ-GT IGF-1 anagen phase SCF antigen expression biomarkers minoxidil peppermint oil rosemary oil insulin-like growth factor 1 alkaline phosphatase gamma-glutamyl transferase
TLDR Certain enzymes and a growth factor were higher in mice treated with minoxidil or a peppermint and rosemary oil mix, which may be good indicators of hair growth.
The 2008 study investigated the correlation between enzyme activities and gene expression with hair growth in a shaving animal model of C57BL/6 mice. The mice were divided into four groups: normal (saline), vehicle control (jojoba oil), positive control (3% minoxidil), and experimental (3% mixture oil of peppermint and rosemary in jojoba oil). The study found that ALP and γ-GT activities and IGF-1 expression in the anagen phase were significantly increased in the positive control and experimental groups compared to the normal or vehicle control group (p<0.05). The parts and degree of SCF antigen expression were more extensive and stronger in the experimental and positive control groups compared to the normal or vehicle control group. The results suggested that ALP and γ-GT activities and IGF-1 expression were well correlated to the degree of hair growth and good biomarkers in the anagen phase.
