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    Glossary Spermidine

    naturally occurring compound aiding cellular growth and hair health

    Spermidine is a naturally occurring polyamine compound found in ribosomes and living tissues, which plays a critical role in cellular growth, proliferation, and differentiation. It has been studied for its potential benefits in promoting hair growth and combating hair loss, as it can enhance autophagy, a cellular process that removes damaged components and supports cell renewal.

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    Research 30 of 182

    1. Spermidine/spermine-<i>N</i><sup>1</sup>-acetyltransferase: a key metabolic regulator AJP Endocrinology and Metabolism · 2008 · 305 citations
    2. Genetically Altered Expression of Spermidine/Spermine N1-Acetyltransferase Affects Fat Metabolism in Mice via Acetyl-CoA Journal of Biological Chemistry · 2006 · 128 citations
    3. Activation of Polyamine Catabolism Profoundly Alters Tissue Polyamine Pools and Affects Hair Growth and Female Fertility in Transgenic Mice Overexpressing Spermidine/SpermineN 1-Acetyltransferase Journal of Biological Chemistry · 1997 · 124 citations
    4. Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions PLOS ONE · 2011 · 61 citations
    5. Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis Carcinogenesis · 2002 · 54 citations
    6. Relation of Skin Polyamines to the Hairless Phenotype in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase Journal of Investigative Dermatology · 2001 · 54 citations
    7. Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue Biochemical Journal · 1999 · 43 citations
    8. Disturbed Keratinocyte Differentiation in Transgenic Mice and Organotypic Keratinocyte Cultures as a Result of Spermidine/Spermine N1-Acetyltransferase Overexpression Journal of Investigative Dermatology · 2005 · 37 citations
    9. Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length GeroScience · 2021 · 20 citations
    10. N1-methylspermidine, a stable spermidine analog, prolongs anagen and regulates epithelial stem cell functions in human hair follicles Archives of dermatological research · 2015 · 13 citations
    11. Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue Biochemical Journal · 1999 · 13 citations
    12. A spermidine-based nutritional supplement prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-blind study Dermatology practical & conceptual · 2017 · 8 citations
    13. Scientific Opinion on the substantiation of health claims related to spermidine and contribution to normal hair growth (ID 1705) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 EFSA Journal · 2011 · 3 citations
    14. The effects of intradermal injections of spermidine on the growth rate of fibres and mitosis of wool follicles in Merino lambs Animal Science · 2002 · 3 citations
    15. Expression and distribution patterns of spermine, spermidine, and putrescine in rat hair follicle Histochemistry and Cell Biology · 2017 · 2 citations
    16. Capillary gas‐chromatographic determination of spermidine in hair lotion Journal of Separation Science · 2006 · 2 citations
    17. Scientific Opinion on the substantiation of a health claim related to spermidine and prolongation of the growing phase (anagen) of the hair cycle pursuant to Article 13(5) of Regulation (EC) No 1924/2006 EFSA Journal · 2011 · 1 citations
    18. The Effects of Spermidine on Functional and Transcriptomic Markers in Human Primary Keratinocytes Physiologia · 2025
    19. Oral Spermidine Supplementation Prolongs Hair Follicle Anagen Phase with Sustained Effects: A Randomized, Double-Blind, Placebo-Controlled Trial MEDS Public Health and Preventive Medicine · 2025
    20. Response to comments on the Scientific Opinion on the substantiation of a health claim related to spermidine and prolongation of the growing phase (anagen) of the hair cycle pursuant to Article 13(5) of Regulation (EC) No 1924/2006 EFSA supporting publications · 2012
    21. Topical spermine and putrescine stimulated DNA synthesis in the hairless mouse epidermis British Journal of Dermatology · 1980 · 10 citations
    22. Spermine Lipid Assembled Nanoparticles for siRNA Delivery and Androgenetic Alopecia Therapy ACS Applied Materials & Interfaces · 2026
    23. Relevance of the Axis Spermidine/eIF5A for Plant Growth and Development Frontiers in Plant Science · 2016 · 19 citations
    24. Activated Polyamine Catabolism Depletes Acetyl-CoA Pools and Suppresses Prostate Tumor Growth in TRAMP Mice Journal of Biological Chemistry · 2004 · 91 citations
    25. Inhibition of Polyamine Synthesis Alters Hair Follicle Function and Fiber Composition Journal of Investigative Dermatology · 1996 · 42 citations
    26. Polyamines and hair: a couple in search of perfection Experimental Dermatology · 2010 · 30 citations
    27. Synthetic studies toward the development of novel minoxidil analogs and conjugates with polyamines Tetrahedron Letters · 2010 · 12 citations
    28. Increased hair polyamine levels in patients with alzheimer's disease Annals of neurology · 2001 · 10 citations
    29. Synthesis of minoxidil conjugates and their evaluation as HL-60 differentiation agents Bioorganic & Medicinal Chemistry Letters · 2016 · 6 citations
    30. Value of Nutrition-Based Therapies for Hair Growth, Color, and Quality 2020 · 2 citations