The Effects of Intradermal Injections of Spermidine on the Growth Rate of Fibers and Mitosis of Wool Follicles in Merino Lambs

April 2002 in “ Animal Science ”

S. M. Liu, Ashley Murray, A. C. Schlink, G. Mata, DG Masters

spermidine intradermal injections cell division wool follicles skin homeostasis cell proliferation

TLDR Spermidine injections increased wool growth rate in lambs without changing fibre thickness.

The study on Merino lambs demonstrated that intradermal injections of spermidine increased the concentration of spermidine in the skin, which stimulated cell division in wool follicles and resulted in a higher fibre length growth rate compared to the saline control. Despite these changes, there was no significant effect on fibre diameter. The findings indicated that spermidine altered skin homeostasis and enhanced cell proliferation, leading to increased fibre growth rate without affecting the diameter.

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