The Effects of Intradermal Injections of Spermidine on the Growth Rate of Fibers and Mitosis of Wool Follicles in Merino Lambs

April 2002 in “ Animal Science ”

S. M. Liu, Ashley Murray, A. C. Schlink, G. Mata, DG Masters

spermidine intradermal injections cell division wool follicles skin homeostasis cell proliferation

Studysummary This study found that intradermal spermidine injections stimulated cell proliferation and increased fibre length growth rate in wool follicles of Merino lambs, without significantly affecting fibre diameter.

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research Relation of Skin Polyamines to the Hairless Phenotype in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase

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research Ornithine Decarboxylase Transgenic Mice as a Model for Human Atrichia with Papular Lesions

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This study observed that overexpression of the enzyme ODC in transgenic mice caused hair loss and skin changes similar to human papular atrichia, suggesting that ODC might be involved in a critical hair follicle function pathway.

research Overexpression of Spermidine/Spermine N1-Acetyltransferase Under the Control of Mouse Metallothionein I Promoter in Transgenic Mice: Evidence for a Striking Post-Transcriptional Regulation of Transgene Expression by a Polyamine Analogue

43 citations , February 1999 in “Biochemical Journal”

This study found that transgenic mice overexpressing the SSAT gene under a metallothionein promoter suffered delayed hair loss and were highly sensitive to polyamine analogues, which led to significant liver changes and mortality.

research Activation of Polyamine Catabolism Profoundly Alters Tissue Polyamine Pools and Affects Hair Growth and Female Fertility in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase

124 citations , July 1997 in “Journal of Biological Chemistry”

This study found that overexpression of an enzyme in transgenic mice led to distorted polyamine levels, resulting in permanent hair loss and female infertility.

research Inhibition of Polyamine Synthesis Alters Hair Follicle Function and Fiber Composition

42 citations , February 1996 in “Journal of Investigative Dermatology”

This study found that spermidine, a polyamine, plays an essential role in hair growth in sheep follicles, while spermine is not required for normal follicle function.