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This study found that the combination of letrozole and quercetin loaded in spanlastics showed enhanced cytotoxicity and other anticancer effects against MCF-7 breast cancer cells compared to individual treatments.

This study optimized efinaconazole spanlastic nanovesicles using risk management and multivariate analysis for potential transungual delivery to treat onychomycosis, achieving improved drug permeability and dissolution efficiency.

This study found that using spanlastics, a nano, surfactant-based drug delivery system, improved the bioavailability, drug release characteristics, and pharmacokinetic behavior of famotidine, a poorly soluble drug, by enhancing its dissolution and membrane permeation.

This study developed cilostazol-loaded formulations for nose-to-brain delivery, finding that these formulations improved cilostazol's bioavailability by enhancing solubility, absorption, and permeability, achieving nearly 100% drug release in vitro within 2 hours.

This case report documents a rare association between atopic eczema and pili annulati in two siblings from north India, an unusual finding not previously reported in the literature.

This study evaluated green tea extract-loaded spanlastic formulations and found that a vesicle builder to edge activator ratio of 8:2 produced optimal characteristics, including a particle size of 419.70 nm, an entrapment efficiency of 60.85%, and a drug loading of 11.07%.

This study found that spanlastic gel loaded with thymoquinone and ascorbic acid improved skin deposition and tyrosinase inhibition, suggesting potential as a treatment for hyperpigmentation.

In this study, the researchers successfully developed a Spanlastic gel containing EGCG for transdermal application, significantly increasing EGCG skin permeability with optimal entrapment efficiency, zeta potential, and vesicle size.

In this quasi-experimental study, researchers explored the optimal formulation of a nanoemulsion containing candlenut ethanol extract, finding that specific combinations of tween 80, span 80, and sonication time affected its physical properties and stability, although further activity testing is needed.

This study explored the use of spanlastic vesicles to enhance the delivery of bimatoprost for treating alopecia and found that a bimatoprost-loaded nanogel significantly increased skin drug accumulation and improved hair regrowth in a mouse model, outperforming both naive bimatoprost gel and commercial minoxidil formulations.

This review discusses spanlastics, advanced elastic vesicles used in drug delivery to enhance bioavailability of poorly soluble drugs, offering improved stability and targeted delivery compared to traditional systems like liposomes and nanoparticles, thus reducing side effects and enhancing therapeutic outcomes.

This study developed the SAALIQ, a culturally adapted tool specifically for measuring quality of life in Spanish-speaking patients with alopecia areata, highlighting its strong psychometric performance and the benefit of capturing overlooked domains compared to generic measures.

This review highlights the potential of spanlastics, a new type of drug delivery system, to enhance drug administration by offering better deformability and stability compared to other nanocarriers, potentially improving targeted drug delivery across various applications.

This study reported the discovery of large-scale haplotypes (cenhaps) in human centromere regions, revealing deep genetic diversity, including introgressed Neanderthal and ancient African lineages.

This study demonstrated that a new topical treatment using ketotifen-loaded microneedles, designed for prolonged release, significantly reduced inflammatory markers in an animal model of allergic conjunctivitis, suggesting enhanced therapeutic delivery and sustained ocular benefits.

This study found that human centromeric regions exhibit large-scale haplotypes with significant diversity, including entire Neanderthal haplotypes, which may affect chromosome transmission.

This study found that curcumin spanlastics demonstrated greater antimicrobial, antioxidant, and anticancer activities in the MCF-7 breast cancer cell line compared to curcumin alone or curcumin nanocrystals, also affecting several cancer-related protein markers and showing enhanced solubility and activity.

This study found that the meropenem-loaded spanlastic formulation showed strong potential as an effective topical therapy for bacterial skin infections in non-diabetic mice, demonstrating superior therapeutic activity and wound healing compared to free meropenem.

This study found that topical valproic acid and 5% minoxidil both significantly increased hair count in patients with female pattern hair loss, suggesting topical valproic acid as a potential treatment option.

This study found that treating mtDNA mutator mice with the antioxidant SkQ1 delayed aging traits and extended their lifespan, potentially by alleviating mitochondrial dysfunction caused by reactive oxygen species.

This article discusses the impact of trichotillomania on children, highlighting significant impairment and distress, but reports no new clinical findings.

This study examined the Spanish Merino breed's wool quality, identifying 74 genetic variants linked to key wool traits like fiber diameter and staple length, which could help restore the breed's potential for producing high-quality wool.

This study investigated spanlastic nanovascular drug delivery systems and found that they can effectively enhance the transport and continuous release of medicines with small particle size, low polydispersity index, and satisfactory entrapment efficiency, showing potential as carriers for drug delivery.

This study validated a Spanish version of the Hair Specific Skindex 29 scale for assessing quality of life in women with female androgenetic alopecia, showing similar psychometric properties to the original.

This study found that the most significant negative emotional responses among cancer patients during consultations were related to treatment delays and the possibility of hair loss.

This consensus from 22 Spanish dermatologists recommends using a multimodal therapy starting with oral dutasteride, combined with topical and/or intralesional agents, and adding hydroxychloroquine if inflammation persists, to manage frontal fibrosing alopecia due to its irreversible hair loss and lack of specific approved treatments.

In this study, the authors successfully translated, culturally adapted, and validated the Women's Androgenetic Alopecia Quality of Life questionnaire into Spanish, demonstrating it as a reliable tool for assessing female pattern hair loss.

This review outlines dermatological toxicities associated with targeted cancer therapies and immunotherapies, emphasizing the need for collaborative management by oncologists and dermatologists but reports no new clinical findings.

This study presents the first reported Spanish case of Hypotrichosis with Juvenile Macular Dystrophy, identifying a new CDH3 mutation and highlighting the importance of clinical and genetic evaluation for accurate diagnosis.

This study identified a new PNPLA1 mutation in a Spanish family with autosomal recessive congenital ichthyosis.