TLDR SkQ1 antioxidant improved health and lifespan in mice.
The study demonstrated that treating mtDNA mutator mice with the mitochondrially targeted antioxidant SkQ1 significantly improved their health-span and lifespan. SkQ1 treatment delayed aging traits, improved heart, kidney, and liver pathologies, preserved mitochondrial ultrastructure, and enhanced mitochondrial function. Treated mice lived significantly longer (335 vs. 290 days) and showed reduced oxidative damage markers. The findings suggested that SkQ1 could mitigate mitochondrial dysfunction and oxidative stress, offering potential therapeutic benefits for age-related diseases and conditions linked to mitochondrial damage.
53 citations,
October 2014 in “Free radical biology & medicine” Defective mitochondrial DNA replication causes aging symptoms and increased oxidative damage in mice.
437 citations,
August 2014 in “Cell metabolism” Turning white fat into brown-like fat could help fight obesity and type 2 diabetes.
March 2024 in “International journal of molecular sciences” Mitochondrial dysfunction is linked to various skin conditions and could be a target for treatments.
280 citations,
July 2018 in “Antioxidants” Treatments that reduce oxidative stress and fix mitochondrial problems may help heal chronic wounds.
42 citations,
December 2016 in “Cell Death & Differentiation” Damaging mitochondrial DNA in mice speeds up aging due to increased reactive oxygen species, not through the p53/p21 pathway.
January 2017 in “Elsevier eBooks” Antioxidants may help improve mitochondrial health and could be used to treat diseases related to cell damage.
39 citations,
October 2015 in “Case Reports” Some people experience severe, long-lasting side effects from fluoroquinolone antibiotics, leading to the recommendation of limited use and increased awareness of these risks.
