Improved Health-Span and Lifespan in mtDNA Mutator Mice Treated with the Mitochondrially Targeted Antioxidant SkQ1

February 2017 in “ Aging ”

Irina G. Shabalina, Mikhail Yu. Vyssokikh, N. V. Gibanova, Robert I. Csikasz, Daniel Edgar, Anne Hallden-Waldemarson, Zinaida Rozhdestvenskaya, L. E. Bakeeva, V. B. Vays, Antonina V. Pustovidko, М. В. Скулачев, Barbara Cannon, Vladimir P. Skulachev, Jan Nedergaard

mitochondrially targeted antioxidant SkQ1 mtDNA mutator mice mitochondrial dysfunction oxidative stress mitochondrial ultrastructure oxidative damage markers

TLDR SkQ1 antioxidant improved health and lifespan in mice.

The study demonstrated that treating mtDNA mutator mice with the mitochondrially targeted antioxidant SkQ1 significantly improved their health-span and lifespan. SkQ1 treatment delayed aging traits, improved heart, kidney, and liver pathologies, preserved mitochondrial ultrastructure, and enhanced mitochondrial function. Treated mice lived significantly longer (335 vs. 290 days) and showed reduced oxidative damage markers. The findings suggested that SkQ1 could mitigate mitochondrial dysfunction and oxidative stress, offering potential therapeutic benefits for age-related diseases and conditions linked to mitochondrial damage.

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