Improved Health-Span and Lifespan in mtDNA Mutator Mice Treated with the Mitochondrially Targeted Antioxidant SkQ1

February 2017 in “ Aging ”

Irina G. Shabalina, Mikhail Yu. Vyssokikh, N. V. Gibanova, Robert I. Csikasz, Daniel Edgar, Anne Hallden-Waldemarson, Zinaida Rozhdestvenskaya, L. E. Bakeeva, V. B. Vays, Antonina V. Pustovidko, М. В. Скулачев, Barbara Cannon, Vladimir P. Skulachev, Jan Nedergaard

mitochondrially targeted antioxidant SkQ1 mtDNA mutator mice mitochondrial dysfunction oxidative stress mitochondrial ultrastructure oxidative damage markers

TLDR SkQ1 antioxidant improved health and lifespan in mice.

The study demonstrated that treating mtDNA mutator mice with the mitochondrially targeted antioxidant SkQ1 significantly improved their health-span and lifespan. SkQ1 treatment delayed aging traits, improved heart, kidney, and liver pathologies, preserved mitochondrial ultrastructure, and enhanced mitochondrial function. Treated mice lived significantly longer (335 vs. 290 days) and showed reduced oxidative damage markers. The findings suggested that SkQ1 could mitigate mitochondrial dysfunction and oxidative stress, offering potential therapeutic benefits for age-related diseases and conditions linked to mitochondrial damage.

View this study on aging-us.com →

Discuss this study in the Community →

Research cited in this study

2 / 2 results

research Defects in Mitochondrial DNA Replication and Oxidative Damage in Muscle of mtDNA Mutator Mice

53 citations , October 2014 in “Free radical biology & medicine”

Defective mitochondrial DNA replication causes aging symptoms and increased oxidative damage in mice.

research The Browning of White Adipose Tissue: Some Burning Issues

437 citations , August 2014 in “Cell metabolism”

Turning white fat into brown-like fat could help fight obesity and type 2 diabetes.

Related Community Posts Join

6 / 53 results

community Cell senescence-targeted treatment for hair loss, has anyone tried any products/enzymes etc. that use this theory

in Research/Science 4 upvotes 7 months ago

DHT causes hair loss by driving cells into senescence, and a polyphenol in black chokeberry may reverse this. A product using this theory is being considered for use alongside finasteride, minoxidil, and microneedling.

community If PP405 goes systemic this would be quite catastrophic

in Research/Science 5 upvotes 10 months ago

Concerns about the potential systemic effects and safety of PP405 for hair loss, with discussions on its comparison to existing treatments like finasteride and minoxidil. Users express skepticism about untested research chemicals and emphasize the importance of clinical trials to ensure safety and efficacy.

community A science based addition to your hair loss routine

in Research/Science 23 upvotes 1 year ago

Blocking the Mitochondrial pyruvate carrier and using aldose reductase inhibitors like Indian gooseberry and berberine may help with hair growth. Magnesium can also be added to increase NADPH.

community The mechanism of androgenic alopecia

in Research/Science 35 upvotes 1 month ago

DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

community PP405 Identity Research

in Research 292 upvotes 3 months ago

PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 98 upvotes 5 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

Similar Research

5 / 1000+ results

research Progress on Mitochondria and Hair Follicle Development in Androgenetic Alopecia: Relationships and Therapeutic Perspectives

February 2025 in “Stem Cell Research & Therapy”

Maintaining healthy mitochondria may help treat hair loss.

research Dermatologic Manifestations of Mitochondrial Dysfunction: A Review of the Literature

March 2024 in “International journal of molecular sciences”

Mitochondrial dysfunction is linked to various skin conditions and could be a target for treatments.

research Targeting Oxidative Stress and Mitochondrial Dysfunction in the Treatment of Impaired Wound Healing: A Systematic Review

280 citations , July 2018 in “Antioxidants”

Treatments that reduce oxidative stress and fix mitochondrial problems may help heal chronic wounds.

Transient Mitochondrial DNA Double Strand Breaks in Mice Cause Accelerated Aging Phenotypes in a ROS-Dependent but p53/p21-Independent Manner

research Transient Mitochondrial DNA Double Strand Breaks in Mice Cause Accelerated Aging Phenotypes in a ROS-Dependent but p53/p21-Independent Manner

42 citations , December 2016 in “Cell Death & Differentiation”

Damaging mitochondrial DNA in mice speeds up aging due to increased reactive oxygen species, not through the p53/p21 pathway.

Antioxidants and Mitochondrial Bioenergetics: Charnoly Bodies in Neurodegenerative Diseases, Cardiovascular Disorders, and Cancer

research Antioxidants and Mitochondrial Bioenergetics: Charnoly Bodies in Neurodegenerative Diseases, Cardiovascular Disorders, and Cancer

January 2017 in “Elsevier eBooks”

Antioxidants may help improve mitochondrial health and could be used to treat diseases related to cell damage.