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In this study, a novel homozygous mutation in the STAT5B gene was identified in a 17-year-old boy with growth hormone-refractory growth failure, severe eczema, and autoimmune disease, suggesting a similarity to known STAT5B deficiency phenotypes.

This review examines the dysregulation of innate immune barriers in the early stages of hidradenitis suppurativa and calls for further research on the role of the hair follicle and immune responses, but reports no new results.

This review hypothesizes that excessive facial photo-protection may contribute to frontal fibrosing alopecia by disrupting immunological homeostasis through the aryl hydrocarbon receptor-kynurenine pathway, but it reports no new clinical results.

This review synthesizes current advances in transcriptomics and RNA regulatory networks, alongside stem cell-derived skin organoid research, to propose a conceptual framework for understanding and potentially guiding regenerative skin repair, without claiming clinical readiness.

In this laboratory study, researchers observed that mouse vascular endothelial cells exhibit dynamic changes after exposure to ionizing radiation, including a transient endothelial subpopulation that facilitates vascular-epidermal communication and skin repair, with shifting roles in angiogenesis and immune surveillance over time.

In this study, researchers found that Ectoin, derived from halophilic bacteria, can mitigate stress-related skin damage by reducing cortisone's inhibitory effects on essential skin proteins and decreasing UVB-induced glucocorticoid activity, highlighting its potential as a preventative agent for stress-induced skin issues.

This study suggests that abnormal levels of zinc, copper, and iron in serum or hair may serve as auxiliary and prognostic tests for various skin diseases, though further research is necessary due to conflicting data.

iNKT cells help develop and maintain healthy skin in young mice.

This study synthesizes knowledge of how dendritic cell signals, epithelial integrins, and fibroblast activity converge on TGF-β1 to maintain or disrupt skin healing, contrasting normal and fibrotic scar formation and suggesting possible integrin and immune-targeted treatments for skin fibrosis.

This review explores recent advancements in understanding how various physiological and psychological factors, such as stress and aging, influence epidermal stem cell populations, highlighting their importance in immune-related skin disorders and potential for clinical applications.

This review discusses the potential of single cell technologies to improve understanding and treatment of impaired wound healing and reports no new clinical results.

This study found that D-peptide crosslinked MAP hydrogel accelerated material degradation in vivo but significantly enhanced skin regeneration, suggesting an adaptive immune response can drive regenerative healing even with rapid scaffold breakdown.

The research found that hair follicle–derived cytokines, particularly IL-15 and IL-7, regulate skin-resident memory T cells and their role in both immune homeostasis and lymphoma in the skin.

This review explores the biological functions of vitamin D, highlighting how deficiency may increase the risk of various diseases, but reports no new clinical results.

This review discusses recent findings on the plasticity and regulation of epithelial stem cells and reports no new experimental results.

This review discusses the mechanisms of wound healing and excessive scarring, highlighting the importance of understanding these processes for developing new therapies to prevent fibrotic scarring in large skin wounds.

This article reviews the current status of oral retinoids in dermatology and reports no new clinical findings.

This review discusses the complex pathophysiological and clinical aspects of COVID-19, including dermatological findings and their association with SARS-CoV-2 infection but reports no new clinical results.

This review discusses how tissue resident memory T cells contribute to autoimmune skin diseases like vitiligo and psoriasis, highlighting their role in continuous immune activation, and reports no new clinical results.

This paper discusses the evolving understanding of psoriasis pathogenesis with no new clinical findings; the authors highlight the role of T-cell plasticity and regulatory cells, calling for further clinical applications using single-cell technologies.

This review discusses the mechanisms behind alopecia areata and primary cicatricial alopecia and reports no new clinical results, aiming to guide the development of targeted treatments.

This study found that EGFR-targeted cancer therapy can cause skin toxicities by disrupting epidermal signaling, allowing microbiota invasion and inflammation, but identified a potential treatment approach using FGF7 or SOS expression to restore barrier integrity.

In this study, adipose-derived stem cells from superficial adipose tissue showed higher regenerative potential, and more macrophages were found in superficial than deep adipose tissue, potentially influenced by skin microbiota.

This study identified novel biomarkers through gene expression differences between keratinocytes and fibroblasts in newborn mice, which may aid in developing therapies for skin conditions.

In this study, Korean red ginseng was observed to improve skin hydration and reduce both the severity of atopic dermatitis and serum IgE levels after 16 weeks in patients with the condition.

This study suggests that erlotinib exacerbates inflammation in a mouse model of skin disease and that IL-1 inhibition could mitigate skin-related side effects of EGFR inhibitors.

This review discusses the role of vitamin D metabolism in skin immunity and wound healing but does not present new results, highlighting the need for further research into its therapeutic applications.

This review discusses the role of the TRPV4 channel in skin physiology and pathology, highlighting its potential as a therapeutic target for skin disorders, but reports no new clinical results.

This study found that integrin-linked kinase is crucial for various epidermal functions, including differentiation and barrier formation, and also plays a previously unreported role in melanocyte development and function.

This case report presents the first evidence of significant antigen presenting cells around hair follicles in a patient with alopecia due to active systemic lupus erythematosus.