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The conclusion is that accurately replicating the complexity of the extracellular matrix in the lab is crucial for creating realistic human tissue models.

Hair follicles are valuable for regenerative medicine and wound healing.

The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.

Standardized procedures are crucial for collecting and preparing biological samples to ensure accurate clinical metabolomics results.

The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.

Maxillariinae orchids contain 62 compounds with potential health benefits, including treating skin conditions and diseases like cancer and diabetes.

Skin-derived stem cells can become various cell types, including germ cell-like and oocyte-like cells.

Bioactive molecules show promise for improving skin repair and regeneration by overcoming current challenges with further research.

Different stem cells have benefits and challenges for tissue repair, and more research is needed to find the best types for each use.

Clinicians should use social and prescription data to track trends in performance-enhancing drug use.

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

Vav2 and Vav3 proteins help control skin stem cell numbers and activity in both healthy and cancerous cells.

Vismodegib is effective for basal cell carcinoma but has severe side effects.

New treatments for PCOS focus on insulin resistance and reducing testosterone levels, along with traditional hormone therapies.

*Acorus calamus* has many medicinal benefits but needs more safety research.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Skin-derived stem cells grow faster and are easier to obtain than hair follicle stem cells, but both can become various cell types.

There are various effective hormone treatments for puberty induction in boys and girls with hypogonadism, and starting treatment early is important.

Fat-derived stem cells may help treat skin aging and hair loss.

Plant-based compounds can improve wound dressings and skin medication delivery.

Early treatment of acne is crucial to prevent scarring and psychological effects.

Changes in gut bacteria can contribute to the development of Polycystic Ovary Syndrome (PCOS), affecting metabolism, immunity, and causing inflammation. Treatments may involve adjusting these factors.

EDA signaling is linked to skin disorders, various cancers, and liver disease.

Vav2 changes how hair follicle stem cells' genes work as they age, which might improve regeneration but also raise cancer risk.

Understanding and managing side effects of hedgehog pathway inhibitors can improve treatment for advanced basal cell carcinoma.

Personalized diets, like the Mediterranean Diet and low carb diets, can help manage PCOS symptoms in obese women, and probiotics may enhance weight loss and improve metabolic health. More research is needed to find the best diet strategies.

Some skin diseases and their treatments can negatively affect male fertility.

Adult female acne is complex and requires a combination of treatments for effective management.

PCOS is linked to diabetes and insulin resistance, and managing AGEs may help treat related symptoms.

Insulin resistance and high male hormone levels are major causes of Polycystic Ovary Syndrome.