8 citations
,
September 2011 in “Scanning” This study found that multiphoton microscopy effectively visualizes the microstructure of in vivo mouse skin, offering a clear view of various skin layers and components like corneocytes and collagen fibers.
2 citations
,
July 2017 in “IEEE Photonics Journal” This study found that combining second-harmonic generation with optical coherence tomography may effectively evaluate wound healing by monitoring collagen formation and optical signal changes in regenerated tissue.
September 2023 in “Biomedical Optics Express” This study used non-invasive imaging techniques to assess hair follicle characteristics in AGA mice, revealing delayed hair shaft alternation and growth stages, as well as testosterone-induced follicle miniaturization, offering potential methods for evaluating AGA on human scalps in vivo.
February 2026 in “Optics” This study demonstrates that polarized second harmonic generation imaging effectively monitors wool fiber stretching, revealing significant structural changes in keratin alignment that improve textile performance.
18 citations
,
September 2013 in “Technology” This study introduces a new multimodal imaging technology to visualize and quantify cell dynamics in natural skin over long durations, demonstrated in GFP bone marrow-transplanted mice, to study dynamic skin regeneration.
13 citations
,
September 2021 in “Communications Biology” This study introduces a five-modal microscopy technique that allows label-free, in vivo observation and quantitative analysis of various wound healing processes.
2 citations
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December 2024 in “Microscopy Research and Technique” This study introduced a novel microscopy system using an Er3 + −doped femtosecond fiber laser, achieving detailed imaging of biological structures in plant and skin samples with improved spatial resolution for various applications, including in vivo imaging.
2 citations
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September 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study investigated various animal tissues from adult mice and embryonic chicks, finding that tissue stiffness follows a sub-linear power law relationship with Collagen-I levels, consistent with cellularized collagen gels but not acellular ones.
1 citations
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April 2017 in “Journal of Investigative Dermatology” This study evaluated the effects of topical glucocorticoids on human skin using non-invasive imaging methods and observed changes such as alterations in skin layer thickness, keratinocyte size, and collagen and elastin signal intensity.
September 2025 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers developed non-invasive methods to monitor hair shaft, melanin, and collagen dynamics in C57BL/6 mice across different hair follicle cycle phases, supporting non-invasive research in hair loss treatment development.
February 2012 in “Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE” This study observed nestin-GFP expressing stem cells in the hair follicle bulge of living mice using high-resolution in-vivo multiphoton tomography, allowing migration tracking within their natural skin environment.
3 citations
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July 2024 in “Annals of Biomedical Engineering” This study found that multiphoton microscopy imaging allows for detailed observation and quantitative analysis of collagen alterations in the progression of endometrial cancer, potentially offering a faster, more accurate method for early diagnosis compared to current protocols.
1 citations
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August 2024 in “Lasers in Surgery and Medicine” This study observed that calcium hydroxylapatite can be successfully incorporated and retained in the dermis for at least six weeks after fractional laser treatment, with new collagen forming around it.
January 2024 in “Wiadomości Lekarskie” This study reported the development of fluorescent markers using wide band gap metal oxides with rare earth ions for early tumor detection and treatment. Testing in animals showed high efficiency and selectivity, with potential applications in contrast-enhanced MRI, targeted drug delivery, and photodynamic cancer therapy.
January 2024 in “Wiadomości Lekarskie” This research highlights major advancements in vaccinology, such as mRNA vaccines and nanoparticle delivery systems, enhancing vaccine efficacy and paving the way for novel vaccine development against infectious and non-infectious diseases like cancer, with implications for improved global health outcomes.
In this study, researchers developed a method to create a synthetic dataset of facial acne images using generative techniques, achieving 97.6% classification accuracy with InceptionResNetv2, which helps overcome privacy concerns in biomedical applications by using anonymized data.
This study presents a new approach to automatically remove hair artifacts from dermoscopic images, which reportedly performed well compared to existing methods like DullRazor using the PH2 datasets.
This study introduced a new computational method for simulating vibrational frequencies, finding that the multi-molecular fragment model showed the best agreement with experimental data for Finasteride, Lamivudine, and Repaglinide, outperforming traditional models in accuracy.
January 2024 in “Wiadomości Lekarskie” This study discusses current surgical treatments for ischemic stroke, emphasizing the confirmed effectiveness of mechanical thrombectomy, and notes that advances in early recognition and rapid intervention at specialized stroke centers have significantly reduced mortality rates in recent decades.
2 citations
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September 2024 in “Diagnostics” This study proposes a new mathematical model, the Harmonic Mean equation, for precisely quantifying nuclear pleomorphism in breast cancer grading, showing high performance with accuracy, recall, specificity, precision, and F1-score metrics.
8 citations
,
February 2019 in “Scientific Reports” This article describes the immunofluorescence tomography method to achieve high-resolution 3-D reconstruction of epithelial tissues and reports no clinical results.
January 2026 in “Inflammation and Regeneration” This review highlights that two-photon excitation microscopy is a valuable tool for visualizing live skin structures and immune responses at high resolution, though its clinical use is hindered by safety and cost issues.
58 citations
,
November 2013 in “Journal of Innovative Optical Health Sciences” This review discusses the development and application of multiphoton microscopy in dermatology, highlighting its advantages and potential future research directions without reporting new clinical results.
1 citations
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December 2014 in “Scanning” This study used multiphoton microscopy to successfully visualize rabbit skin microstructure, highlighting its noninvasive potential for future skin research related to diseases and wound healing.
January 2019 in “The Review of Laser Engineering” This study observed that multiphoton excitation microscopy revealed changes in vascular structure and hair papillae in mice subcutaneous tissue following cyclophosphamide treatment for chemotherapy-induced alopecia.
264 citations
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January 2008 in “Journal of biomedical optics” This study found that ZnO nanoparticles in topical skin products do not penetrate beyond the outer skin layers in humans, suggesting minimal safety concerns for subdermal absorption.
1 citations
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April 2018 in “Lasers in Surgery and Medicine” This review summarizes late-breaking abstracts from the American Society for Laser Medicine and Surgery, 2018, and reports no new clinical findings.
3 citations
,
May 2018 in “InTech eBooks” This review discusses the evaluation of animal models for hair research and regeneration, highlighting their importance and limitations, and calls for improved approaches to advance understanding of human hair diseases.
10 citations
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November 2019 in “Cold Spring Harbor Perspectives in Biology” This review discusses how recent advances in live imaging have revealed the dynamic and adaptable nature of stem cells during various biological processes, and reports no clinical results.
73 citations
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March 2017 in “Scientific Reports” This study demonstrates that bioengineered tooth germ autologously transplanted in a postnatal canine model can achieve functional tooth restoration, suggesting its potential for future clinical regenerative medicine.