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MK-386 reduces sebum DHT levels.

In this study, researchers found no significant differences in serum levels of DHEAs, DHT, and testosterone between female patients with oral lichen planus and healthy controls, suggesting no neuroendocrine etiology linked to the condition.

In this study, researchers found no significant differences in the serum levels of DHEAs, DHT, and testosterone between female patients with oral lichen planus and healthy controls, suggesting no neuroendocrine etiology is associated with this condition.

This research observed that oral testosterone replacement therapy significantly increases cardiovascular risk, while effects of injected or transdermal therapy on cardiovascular risk were not significant, prompting further investigation into these methods.

This study assessed lipid parameters and serum DHT levels in type 2 diabetes patients, but the abstract does not specify the findings about their association.

Dutasteride reduces DHT more effectively than finasteride.

This study found that MK-386 selectively suppressed sebum DHT levels in a dose-dependent manner, suggesting potential use for treating acne.

In this study, ozenoxacin was found to inhibit sebum production in insulin- and 5α-DHT-differentiated hamster sebocytes in a dose-dependent manner, suggesting potential benefits in acne management by combining antimicrobial activity against C. acnes with reduced sebum production.

In this study, researchers found that serum dihydrotestosterone levels were significantly lower in individuals with Type 2 Diabetes compared to healthy controls, with 90% of diabetics displaying subnormal levels.

In this study, finasteride doses as low as 0.2 mg per day significantly reduced both scalp skin and serum DHT levels in men with androgenetic alopecia.

This study found that Bokusoku extract and its compound pentagalloyl glucose inhibited testosterone metabolism and sebum synthesis, suggesting potential therapeutic use for androgen-related acne.

In this study, a topical application of Lotus corniculatus seed extract significantly reduced sebum production and skin oiliness in humans through inhibition of lipid synthesis pathways.

In this study, AGA patients exhibited distinct lipidomic profiles and higher metabolic syndrome prevalence compared to controls, with certain lipids correlated to key AGA-related factors like DHT, PGD2, and TGF-β1.

In this study, administering 5alpha-reductase inhibitors reduced dihydrotestosterone levels and was associated with mild, reversible decreases in semen parameters in healthy men.

This study found that 1-year use of 5alpha-reductase inhibitors, dutasteride or finasteride, significantly lowered dihydrotestosterone levels without adversely affecting bone density, lipids, or hemoglobin in normal men.

This study found that applying a novel 0.25% finasteride solution to the scalp can effectively reduce scalp DHT levels in men with androgenetic alopecia, potentially reducing systemic side-effects.

This study found that among older men, low levels of free dihydrotestosterone were associated with an increased risk of developing atrial fibrillation.

This study found that a 400-mg dose of oral testosterone with dutasteride increases serum testosterone levels for 8–10 hours in hypogonadal men, with the nanomilled formulation unaffected by food, suggesting a practical twice-daily therapy option.

This study concluded that among men with normal testosterone levels, a small increase in serum dihydrotestosterone may reduce symptoms of hypogonadism, suggesting its potential diagnostic use after ruling out hypogonadism.

This study found that in patients with severe aortic valve stenosis, higher serum dihydrotestosterone levels were associated with increased myocardial hypertrophy, fibrosis, and reduced left ventricular function.

This study developed a validated gas chromatography–tandem mass spectrometry assay to assess sex steroid hormones in cerebrospinal fluid, finding substantial levels of DHEA, androstenedione, and testosterone, with strong correlations to serum levels, providing insight into sex steroid dynamics in the human CNS.

This study found that men with vertex baldness had higher serum dihydrotestosterone levels compared to those with frontal baldness, suggesting different hormonal profiles between these two groups in androgenetic alopecia.

In this study, oral finasteride therapy was associated with decreased DHT levels and improved hair loss severity in young male AGA patients, while hormonal changes influenced the curative effect.

This study observed that androgen levels rise with pubic hair development in Tanner stages, differing by sex and age, with DHEA showing a significant prepubertal increase especially in precocious adrenarche.

This study found that spironolactone reduced serum androstenedione and anagen hair shaft diameter in hirsute patients but did not significantly alter unbound testosterone levels, suggesting its effects are primarily peripheral.

In this study, administering dexamethasone rapidly normalized elevated steroid levels in girls with premature adrenarche.

This study suggests that anti-Müllerian hormone (AMH) is the most promising biomarker for diagnosing polycystic ovary syndrome (PCOS), especially in women with phenotype A and D.

This study reported no association between higher serum testosterone or dihydrotestosterone levels and the incidence or progression of lower urinary tract symptoms in asymptomatic or symptomatic men in the REDUCE trial, challenging the belief that elevated androgens contribute to these symptoms.

Opioid use may lower PSA levels, suggesting a possible role in prostate cancer control; PSA testing is useful for detecting prostate cancer; serum triglycerides are not linked to prostate cancer risk; and higher urethral PSA levels may be associated with local hormone activity.

This study found that testosterone therapy improved physical performance, strength, lean body mass, and serum cholesterol in older men with low testosterone levels, with or without the addition of finasteride.