TLDR MK-386 reduces sebum DHT levels.
The study investigated the effects of topical MK-386, an inhibitor of 5α-reductase type I, on sebum dihydrotestosterone (DHT) levels. The research was conducted by a team from Merck Research Laboratories and Pharmaco LSR. The findings indicated that MK-386 effectively suppressed sebum DHT, suggesting its potential utility in conditions related to DHT, such as acne and androgenetic alopecia. However, the document did not specify the number of participants involved in the study, which is crucial for assessing the strength of the findings.
42 citations,
February 1998 in “The Journal of Steroid Biochemistry and Molecular Biology” PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.
49 citations,
January 2004 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.
32 citations,
April 1999 in “Expert Opinion on Investigational Drugs” Finasteride effectively treats male hair loss, improving growth and density.
218 citations,
December 2011 in “Advances in Urology” The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.
3 citations,
January 2001 in “Cambridge University Press eBooks” Finasteride effectively treats hair loss and enlarged prostate in men, with mild side effects.
