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research MK-386, an Inhibitor of 5α-Reductase Type 1, Reduces Dihydrotestosterone Concentrations in Serum and Sebum without Affecting Dihydrotestosterone Concentrations in Semen¹

37 citations , May 1997 in “The Journal of Clinical Endocrinology & Metabolism”

This study found that MK-386 selectively suppressed sebum DHT levels in a dose-dependent manner, suggesting potential use for treating acne.

Effect of MK-386, a Novel Inhibitor of Type 1 5 Alpha-Reductase, Alone and in Combination with Finasteride, on Serum Dihydrotestosterone Concentrations in Men

research Effect of MK-386, a novel inhibitor of type 1 5 alpha-reductase, alone and in combination with finasteride, on serum dihydrotestosterone concentrations in men.

6 citations , August 1996 in “The Journal of Clinical Endocrinology and Metabolism”

MK-386 and finasteride together effectively reduce DHT levels, potentially treating acne and male pattern baldness.

research Topical MK-386 (M), an inhibitor of 5α-reductase (5αr) type I, suppresses sebum dht.

February 1996 in “Clinical Pharmacology & Therapeutics”

MK-386 reduces sebum DHT levels.

research Effect of MK-386, a novel inhibitor of type 1 5 alpha-reductase, alone and in combination with finasteride, on serum dihydrotestosterone concentrations in men

7 citations , August 1996 in “The Journal of Clinical Endocrinology and Metabolism”

research The 5α-Recluctase System and Its Inhibitors

124 citations , January 1996 in “Dermatology”

This article reviews the biochemical properties of 5 alpha-reductase isoforms and highlights the limited dermatological use of inhibitors like finasteride, especially for type 1 isozyme-targeting agents, while suggesting further clinical exploration.

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community Do some people respond better to finasteride than dutasteride? Or the other way around?

in Finasteride/Dutasteride 20 upvotes 3 years ago

The post and conversation are about the effectiveness of finasteride and dutasteride for hair loss. The conclusion is that the user had better results with finasteride and experienced rapid balding after switching to dutasteride.

community My experience with MK-677 and hairloss. (positive, but completely anecdotal)

5 upvotes 11 years ago

MK-677 (Ibutamoren) helped reduce hair shedding and improved muscle growth for the user. The user advises caution, noting increased appetite and potential weight gain without exercise.

community Adding MK 677 for faster micro needle recovery

1 upvotes 1 year ago

The conversation discusses using oral finasteride and topical minoxidil for hair loss, with the addition of MK 677 to potentially speed up recovery and results. It also mentions using ashwagandha to counteract possible cortisol increase and suggests pumpkin seed oil after microneedling.

community Efficacy of Cistanche Tubulosa and Laminaria Japonica Extracts (MK-R7) Supplement in Preventing Patterned Hair Loss and Promoting Scalp Health

1 upvotes 2 years ago

Cistanche Tubulosa and Laminaria Japonica extracts (MK-R7) showed a small increase in hair density but no significant changes in hair thickness or perception. Users are skeptical about its effectiveness unless it's inexpensive, and availability is uncertain.

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