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MK-386 and finasteride together effectively reduce DHT levels, potentially treating acne and male pattern baldness.

MK-386 reduces sebum DHT levels.

Scale created to measure hair loss in men and women; MK-386 reduces acne; Niaspan treats dyslipidemia; minoxidil increases heart rate.

Germacrene analogs, especially 8-Hydroxy germacrene B, are more effective than germacrone at blocking a hormone-related enzyme and could help treat hair loss.

Finasteride effectively treats hair loss and enlarged prostate in men, with mild side effects.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Sebocytes play a key role in controlling androgen levels in human skin.

Hair loss in men is common, treatable, but not curable.

Male hormones, particularly DHT, are linked to male pattern hair loss, and treatments like finasteride can help, but they don't work for postmenopausal women's hair loss, which may have different causes.

Male pattern baldness involves hormones and cell signals affecting hair growth.

Androgenetic alopecia involves genetics, hormones, and can be treated with medications or surgery.

Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Finasteride effectively reduces hair loss by decreasing androgen levels.

Certain drugs that block specific enzymes can help treat prostate diseases.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.

PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

Finasteride effectively treats male hair loss, improving growth and density.

Finasteride potentially treats hair loss by reducing DHT production.

Finasteride inhibits enzyme activity in rhesus macaques, suggesting they're useful for evaluating similar drugs.

Herbal extracts may help hair grow and could be an alternative to synthetic hair loss treatments.

Long-term use of dutasteride for enlarged prostate may worsen blood sugar, cholesterol, and erectile dysfunction.

Finasteride worsens erectile dysfunction and lowers testosterone in men with enlarged prostates, unlike tamsulosin.

New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.

New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.

Using systemic drugs as creams for skin conditions shows promise, but more research is needed to confirm their effectiveness and safety.