Antiandrogens and the Skin

    April 1978 in “ International Journal of Dermatology ”
    Mary Ellen Stewart, Peter E. Pochi
    TLDR Antiandrogens can treat acne, hirsutism, and seborrhea by reducing sebum production and androgen action.
    The document reviewed the effects of antiandrogens on the skin, focusing on their role in treating acne, hirsutism, and seborrhea. It highlighted cyproterone acetate's ability to reduce sebum production and improve symptoms in both male and female subjects by inhibiting androgen action. Additionally, it discussed other antiandrogens like 17α-methyl-B-nortestosterone and flutamide, which influenced sebaceous gland activity, reduced dihydrotestosterone binding in the prostate, and affected sperm fertilizing ability. The review also noted side effects such as gynecomastia and highlighted the potential of antiandrogens in treating advanced prostate carcinoma.
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