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research Local and Systemic Reduction by Topical Finasteride or Flutamide of Hamster Flank Organ Size and Enzyme Activity

37 citations , November 1995 in “Journal of Investigative Dermatology”

Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.

research Androgen Antagonists in Androgen Target Tissues

27 citations , January 1984 in “Pharmacology & Therapeutics”

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

Activity of 17β-(N-Alkyl/Arylformamido) and 17β-[(N-Alkyl/Aryl) Alkyl/Arylamido]-4-Methyl-4-Aza-5α-Androstan-3-Ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear

research Activity of 17β-(N-Alkyl/Arylformamido) and 17β-[(N-Alkyl/Aryl) Alkyl/Arylamido]-4-Methyl-4-Aza-5α-Androstan-3-Ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear

10 citations , August 1998 in “Journal of Investigative Dermatology”

The compounds tested could potentially treat hair loss and alopecia.

research Molecular Interactions of Natural and Synthetic Steroids in Female Hamsters’ Flank Organs

1 citations , March 2012 in “Journal of Dermatological Science”

Testosterone, progesterone, and levonorgestrel change enzyme levels related to fat production in hamster skin, which could affect skin oil and acne.

research Recent Advances in Oxasteroids Chemistry

41 citations , March 2007 in “Steroids”

New methods to make oxasteroids show promise for medical treatments like osteoporosis and breast cancer.

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community Alfatradiol Experience (2 months)

in Treatment 12 upvotes 4 years ago

User experienced side effects from oral finasteride and tried topical Alfatradiol for hair loss. Alfatradiol provided maintenance without significant regrowth, and user suggests it as an alternative for those struggling with finasteride side effects.

community Anyone here who’s using Alfatradiol (17a-Estradiol) in consistency with some results?

in Treatment 7 upvotes 4 years ago

User discusses Alfatradiol (17a-Estradiol) as a potential hair loss treatment with mixed results. Concerns include low dosage, receptor theory, and possible increased aromatase activity on scalp.

community Alfatradiol is a topical 5AR inhibitor that this study shows is effective in stopping hair loss without sides. It can be bought OTC in Europe right now. Thoughts?

10 upvotes 9 years ago

Hair loss treatments, specifically the use of Alfatradiol as an over-the-counter topical 5AR inhibitor that has been shown to be effective in stopping hair loss without side effects. Other treatments discussed include Minoxidil, finasteride and RU58841.

community I think it’s time to drop Pyrilutamide at this point?….

in Update 32 upvotes 3 years ago

A user who has been using Pyrilutamide for 5 months with no results, and other users suggesting they switch to RU58841 or stick to their treatment plan for at least one year.

community Clinical Trial: Clascoterone (Cortexolone 17A-Propionate)

in Research/Science 24 upvotes 1 year ago

A user is joining a clinical trial for Clascoterone, a drug approved for acne but being tested for hair loss. They previously tried finasteride with limited success and plan to share updates on their experience with the new treatment.

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