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The fascial layer is a promising new target for wound healing treatments using biomaterials.

Skin health and repair depend on the signals between skin stem cells and their surrounding cells.

Stem cells help heal skin wounds by moving and changing roles, working with other cells, and needing more research on their activation and behavior.

Porcine acellular dermal matrix treatment helps wounds heal faster and reduces scarring by affecting Jag1 in skin stem cells.

Activating TRPA1 reduces scarring and promotes tissue regeneration.

Wound healing is complex and requires more research to enhance treatment methods.

Immune cells are essential for skin regeneration using biomaterial scaffolds.

Fibroblasts, cells usually linked to tissue repair, also help regenerate various organs and their ability decreases with age. Turning adult fibroblasts back to a younger state could be a new treatment approach.

The gel with icariin speeds up wound healing, reduces scarring, and helps hair growth by controlling BMP4 signaling. It also reduces inflammation and improves wound quality in mice, adapts to different wound shapes, and gradually releases icariin to aid healing. It also prevents too much collagen and myofibroblast formation during skin healing.

Different immune cells like platelets, mast cells, neutrophils, macrophages, T cells, B cells, and innate lymphoid cells all play roles in skin wound healing, but more research is needed due to inconsistent results and the complex nature of the immune response.

Different fibroblasts play key roles in skin healing and scarring.

Silk nanofiber hydrogels help stem cells heal wounds faster and improve skin regeneration.

Stem cell therapy shows promise in improving burn wound healing.

Tiny fat-derived particles can help repair soft tissues by changing immune cell types.

Keratinocytes show more TGF-β system activity and collagen production as they age, which might affect wound scarring.

Sex hormones, especially estradiol, can change chicken feather shapes and colors.

Hydrogel microcapsules help create cells that boost hair growth.

A wearable device using electric stimulation can significantly improve hair growth.

The document concludes that ongoing medical therapy is crucial for preventing hair loss, and surgical options can restore hair, with future treatments for hair loss being promising.

Nanotechnology could improve hair regrowth but faces challenges like complexity and safety concerns.

Certain genes are more active during wound healing in axolotl and Acomys, which could help develop materials that improve human wound healing and regeneration.

Nitric Oxide has potential in medicine, especially for infections and heart treatments, but its short life and delivery challenges limit its use.

Adipose-derived stem cells help heal burns but need more research.

Mice healed without scars as fetuses but developed scars as adults, suggesting scarless healing might be replicated with further research.

Human prenatal skin develops an immune network early on that helps with skin formation and healing without scarring.

Twist2 is essential for proper skin healing and hair growth in developing mice.

Hydrogen peroxide can cause scars by changing healing processes and increasing certain protein levels.

Wounds on the face usually heal with scars, but understanding how some wounds heal without scars could lead to better treatments.

Fetal skin cells from a cell bank heal wounds faster and with less scarring than adult cells.

Future research should focus on making bioengineered skin that completely restores all skin functions.