TLDR Twist2 is essential for proper skin healing and hair growth in developing mice.
The study focused on the role of Twist2 in fetal wound healing and hair follicle development in mice. It was found that Twist2 expression is crucial for proper skin regeneration and hair follicle formation, with upregulation in the dermis at embryonic day 13 (E13) and downregulation at later stages (E15 and E17). Knockdown of Twist2 at E13 led to impaired regeneration and defective hair follicle formation, while Twist2 knockout mice exhibited visible scarring and no hair follicle regeneration. The study also showed that Twist2 knockdown reduced the migratory capacity of dermal fibroblasts, which is essential for wound healing. These findings suggest that Twist2 is a key factor in non-scarring wound healing and hair follicle development in mouse fetuses, with potential implications for regenerative medicine and scarless healing. The experiments were performed in triplicate and statistical significance was set at P<0.05.
301 citations
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February 2019 in “Nature Communications” The research found that different types of fibroblasts are involved in wound healing and that some blood cells can turn into fat cells during this process.
149 citations
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July 2017 in “PLoS Biology” Hair follicle patterns form through a mix of self-organization and signaling interactions.
21 citations
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June 2016 in “Genesis” Researchers identified specific genes that are important for mouse skin cell development and healing.
359 citations
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January 2015 in “Cold Spring Harbor Perspectives in Medicine” Hair growth phase and certain genes can speed up wound healing, while an inflammatory mediator can slow down new hair growth after a wound. Understanding these factors can improve tissue regeneration during wound healing.
1235 citations
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December 2013 in “Nature” Two fibroblast types shape skin structure and repair differently.
207 citations
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March 2012 in “Development” Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.
17 citations
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December 2010 in “Journal of Investigative Dermatology” Flightless I protein affects hair growth, with low levels delaying it and high levels increasing hair length in rodents.
66 citations
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August 2001 in “Experimental Dermatology” Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.
