Twist2 Contributes to Skin Regeneration and Hair Follicle Formation in Mouse Fetuses

    Kento Takaya, Ayano Sunohara, Shigeki Sakai, Noriko Aramaki-Hattori, Keisuke Okabe, Kazuo Kishi
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    TLDR Twist2 is essential for proper skin healing and hair growth in developing mice.
    The study focused on the role of Twist2 in fetal wound healing and hair follicle development in mice. It was found that Twist2 expression is crucial for proper skin regeneration and hair follicle formation, with upregulation in the dermis at embryonic day 13 (E13) and downregulation at later stages (E15 and E17). Knockdown of Twist2 at E13 led to impaired regeneration and defective hair follicle formation, while Twist2 knockout mice exhibited visible scarring and no hair follicle regeneration. The study also showed that Twist2 knockdown reduced the migratory capacity of dermal fibroblasts, which is essential for wound healing. These findings suggest that Twist2 is a key factor in non-scarring wound healing and hair follicle development in mouse fetuses, with potential implications for regenerative medicine and scarless healing. The experiments were performed in triplicate and statistical significance was set at P<0.05.
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