Twist2 Contributes to Skin Regeneration and Hair Follicle Formation in Mouse Fetuses

    March 2024 in “ Research Square (Research Square) ”
    Kento Takaya, Ayano Sunohara, Shigeki Sakai, Noriko Aramaki-Hattori, Keisuke Okabe, Kazuo Kishi
    Image of study
    TLDR Twist2 is essential for proper skin healing and hair growth in developing mice.
    The study focused on the role of Twist2 in fetal wound healing and hair follicle development in mice. It was found that Twist2 expression is crucial for proper skin regeneration and hair follicle formation, with upregulation in the dermis at embryonic day 13 (E13) and downregulation at later stages (E15 and E17). Knockdown of Twist2 at E13 led to impaired regeneration and defective hair follicle formation, while Twist2 knockout mice exhibited visible scarring and no hair follicle regeneration. The study also showed that Twist2 knockdown reduced the migratory capacity of dermal fibroblasts, which is essential for wound healing. These findings suggest that Twist2 is a key factor in non-scarring wound healing and hair follicle development in mouse fetuses, with potential implications for regenerative medicine and scarless healing. The experiments were performed in triplicate and statistical significance was set at P<0.05.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 48 results

      community Three months of consistent minoxidil.

      in Progress Pictures  3124 upvotes 11 months ago
      A user shared progress pictures after three months of using topical minoxidil for hair loss, planning to add dermarolling later. Some responders are skeptical of the rapid hair growth, while others are impressed or question the authenticity of the photos.

      community Should I dedicate my university studies to solving hair loss?

      in Research/Science  373 upvotes 2 years ago
      A 20 year old male who is balding and considering switching to a biology/chemistry program in order to find a low-cost, accessible solution for hair loss. Replies discuss the merits of this idea as well as potential treatments such as Minoxidil, finasteride, RU58841, TM5614, and ADQ.

      community 2.5 years Minoxidil and HRT, CPA->Lupron +Minox 5%

      in Transgender  611 upvotes 3 months ago
      The user experienced significant hair regrowth after 2.5 years of using Minoxidil 5% and hormone replacement therapy (HRT) with Lupron, despite initial scalp irritation. Finasteride was ineffective for them.

      community New Treatments, and a Huge Group Buy with Lots of Research

      in Research/Science  109 upvotes 1 year ago
      A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

    Related Research

    2 / 2 results