Symmetry Breaking of Tissue Mechanics in Wound-Induced Hair Follicle Regeneration

    April 2021 in “ Journal of Investigative Dermatology ”
    Hans I.Chen Harn, Song-Ming Wang, Yue Shi Lai, B. Van Handel, Y. F. Liang, S. Y. Tsai, Ina Maria Schiessl, Amal Sarkar, Hongfei Xi, Michael S. Hughes, S. Kaemmer, Ming Tang, Janos Peti-Peterdi, April D. Pyle, Thomas E. Woolley, Denis Evseenko, Tao Jiang, Cheng-Ming Chuong
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    TLDR Activating TRPA1 reduces scarring and promotes tissue regeneration.
    The document contains summaries of various scientific studies related to regenerative medicine, wound healing, and tissue regeneration. One study found that activating the nociceptor TRPA1 can reduce scar formation and promote tissue regeneration in adult mouse models. Another study investigated the role of Wnt signaling in inducing fibrotic fat loss via DPP4 in skin fibrosis. The document also discusses studies on the mechanics of hair follicle regeneration, the role of Pitx1 in promoting tissue repair and regeneration in skin wounds, and the effects of bacterial infection on wound healing and hair follicle regeneration.
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