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Scientists created a new 3D skin model from cells of plucked hairs that works like real skin and is easier to get.

Lipid nanoparticles can help deliver drugs through hair follicles but struggle to penetrate deeper skin layers.

Different substances can affect how well the skin absorbs minoxidil, a hair loss drug. Caprylic acid helps the skin absorb it the best, followed by propylene glycol and water.

Smaller nanoemulsions can penetrate skin and hair follicles better, which may be useful for delivering drugs and vaccines through the skin.

Mutations in NIPAL4 cause skin issues by disrupting lipid layers, but some improvement is seen with topical treatment.

Niosomes are the most effective at delivering drugs to the skin with minimal absorption into the body.

Nanovesicles improve drug delivery through the skin, offering better treatment outcomes and fewer side effects.

The hydrogel with a 1:3 ratio of hydroxyethyl cellulose to hyaluronic acid is effective for delivering drugs through the skin to treat acne.

CCL5 is important for the hair growth potential of human dermal papilla cells.

Deleting the CRIF1 gene in mice disrupts skin and hair formation, certain proteins affect hair growth, a new compound may improve skin and hair health, blood cell-derived stem cells can create skin-like structures, and hair follicle stem cells come from embryonic cells needing specific signals for development.

Removing the Crif1 gene in mouse skin disrupts skin balance and hair growth.

Applying pseudoceramide improved skin and hair health.

Blood cells turned into stem cells can become skin cells similar to normal ones, potentially helping in skin therapies.

Stem cells can create hair follicles, potentially treating permanent hair loss, and healthy skin and hair depend on mitochondrial function and special fats.

Transcutol-containing vesicles improve minoxidil's skin penetration and hair growth promotion.

A new compound, BOI, can help hair grow by changing hair cycle phases and increasing certain cell contents.

Nanoemulsions with minoxidil and clove oil effectively target hair follicles for better alopecia treatment.

ADSC-derived extracellular vesicles show promise for skin and hair regeneration and wound healing.

Glycerol is essential for skin hydration in mice without sebaceous glands.

The conclusion is that analyzing RNA from skin oils is a promising way to understand skin diseases.

A new non-invasive method can analyze skin mRNA to understand skin diseases better.

Hair lipids do not protect against humidity.

Scalp skin barrier affects hair loss; personalized treatments needed.

Supercritical CO2 extraction makes rice bran oil healthier and safer than traditional methods.

Testosterone therapy improves physical function, strength, and body composition in older men with low testosterone levels.

Male skin gets drier and more alkaline as it ages, which may need different skincare than women's skin.

The document concludes that understanding hair follicles requires more research using computational methods and an integrative approach, considering the current limitations in hair treatment products.

Testosterone therapy aims to treat hormone deficiencies and various conditions safely and effectively, but requires careful patient monitoring due to potential side effects.

Vesicular carriers like liposomes may improve cosmetic skin treatment delivery and effectiveness but need more human research.

Diffusion in artificial sebum is mainly influenced by molecular size and is much faster than in skin lipids.