Human Hair Follicle Regeneration With Trichogenic Human Dermal Papilla Precursor Cells Derived From Induced Pluripotent Stem Cells

May 2017 in “ Journal of Investigative Dermatology ”

Jung-Hyun Kim, B. S. Kang, Y. H. Zheng, Sam K. Jo, Ki Wook Kim, George Cotsarelis, O Jung Kwon

induced pluripotent stem cells trichogenic dermal papilla precursor cells neural crest stem cells epithelial stem cells permanent alopecia mitochondrial function keratinocytes epidermal homeostasis hair follicle morphogenesis pseudoceramide unsaturated fatty acids iPSCs DPPCs NCSCs

TLDR Stem cells can create hair follicles, potentially treating permanent hair loss, and healthy skin and hair depend on mitochondrial function and special fats.

A study from 2017 found that induced pluripotent stem cells (iPSCs) can be differentiated into trichogenic dermal papilla precursor cells (DPPCs) via neural crest stem cells (NCSCs), which can generate human hair follicles when combined with epithelial stem cells. This offers a potential treatment for permanent alopecia patients. Another study found that mitochondrial function in keratinocytes is essential for maintaining epidermal homeostasis and hair follicle morphogenesis. Additionally, a newly developed pseudoceramide with unsaturated fatty acids was found to have beneficial effects on both skin and hair barrier functions.

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