Induced Pluripotent Stem Cell Derived Keratinocyte Differentiation from Reprogrammed Blood Cells

    April 2017 in “ Journal of Investigative Dermatology ”
    J. Jacków, Zongyou Guo, Holly Wobma, Hasan Erbil Abaci, Y. Doucet, Gordana Vunjak‐Novakovic, Angela M. Christiano
    Image of study
    TLDR Blood cells turned into stem cells can become skin cells similar to normal ones, potentially helping in skin therapies.
    The document reports on a study where induced pluripotent stem cells (iPSCs) derived from blood cells reprogrammed with Sendai virus were successfully differentiated into keratinocytes (iPS-KCs). These iPS-KCs, after 60 days of maturation in vitro, expressed levels of KRT14 and p63 comparable to normal human keratinocytes (NHKCs). When used to produce skin equivalents (SEs), the architecture resembled that of normal skin, indicating functional differentiation. This suggests that iPSCs from reprogrammed blood cells can be used to generate keratinocytes that, after a sufficient maturation period, have the potential for use in autologous cell sourcing for stem cell therapies, particularly for conditions like dystrophic epidermolysis bullosa (DEB).
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 432 results

      community Please explain this Minoxidil phenomena

      in Minoxidil  56 upvotes 1 year ago
      The post discusses the difference in effects of Minoxidil (Min) on scalp and facial hair. The user questions why Min-induced hair growth on the scalp is temporary, while facial hair growth seems permanent, even after stopping Min. They propose theories, including different Min mechanisms on body and facial hair, the role of DHT, and the possibility of not achieving fully terminal hair. The responses include personal experiences and theories about Min's effects on hair growth.

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  142 upvotes 10 months ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community 22 yr asian male 2 year fin results

      in Progress Pictures  135 upvotes 1 year ago
      The user "Top_Replacement_7777" shared their positive results with finasteride for hair loss. They asked about maintaining their hair with finasteride and the impact of vaping on hair growth. Another user reassured them that vaping wouldn't affect their progress.

    Similar Research

    5 / 1000+ results