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ZDHHC13 is important for normal liver function and metabolism, affecting mitochondrial activity.

The enzyme DHHC13 is essential for healthy hair and skin, and its deficiency leads to hair loss and skin problems.

The workshop discussed the role of a protein called calreticulin in health and disease, its potential as a treatment target, and its possible use as a disease marker.

Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

Male hormones like testosterone may make COVID-19 worse, and testing for sensitivity to these hormones could help predict how severe a patient's symptoms might be. Treatments that reduce these hormones are being explored.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

Melanoma's complexity requires personalized treatments due to key genetic mutations and tumor-initiating cells.

Estrogen therapy can reduce skin aging but has cancer risks.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

Wnt7a protein is crucial for development and tissue maintenance and plays varying roles in diseases and potential treatments.

Wnt activation shows promise for regenerative medicine but requires selective targeting to minimize risks like cancer.

A mouse gene mutation increases the risk of skin cancer.

The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.

Phloroglucinol may help improve hair loss by promoting hair growth and reducing oxidative stress.

Agouti protein affects melanocortin receptors through competitive antagonism and receptor down-regulation.

Kir6.1 mutations in Cantú syndrome increase channel sensitivity and hyperpolarization, while SUR2B mutations do not.

A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.

Neural progenitor cell-derived nanovesicles help hair growth by activating a key signaling pathway.

New patents show progress in developing drugs targeting the Wnt pathway for diseases like cancer and hair loss.

Mice with too much sPLA₂-IIA have hair loss and poor wound healing due to abnormal hair growth and stem cell depletion.

A new mutation in the TMEM173 gene and a risk allele in IFIH1 cause a unique set of immune-related symptoms.

Hair growth-related cells need the enzyme SCD1 to help maintain the area that supports hair growth.

Wnt signaling is crucial for skin and hair development and its disruption can cause skin tumors.

Skin tumor regression is helped by retinoic acid signaling blocking Wnt signaling.

The environment around melanocyte stem cells is key for hair regeneration and color, with certain injuries affecting hair color and potential treatments for pigmentation disorders.

A specific enzyme is essential for proper hair follicle stem cell development and healthy skin.

Disrupted cholesterol production impairs hair follicle stem cells, leading to hair loss.

WNT10B is linked to cancer development and affects survival and disease progression in various cancers.

Wnt3a protein, when packed in liposomal vesicles, can stimulate hair growth and could potentially treat conditions like hair loss.