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This article provides an overview of bioaesthetics in regenerative medicine, emphasizing the need for rigorous scientific validation for safety and effectiveness without introducing new research results.

In this narrative review, the authors discuss regenerative substances like platelet-rich fibrin and mesenchymal stem cells in biological aesthetics, noting that while these methods show promise for regeneration, their safety, effectiveness, and durability remain uncertain due to limited and heterogeneous evidence.

This review explores the potential of metal nanoparticles as innovative treatments for alopecia, highlighting their effectiveness in promoting hair regrowth, enhancing drug delivery, and modulating gene expression while also assessing the related experimental methodologies and regulatory considerations.

In this study, a new pH-responsive hydrogel composed of polyvinyl alcohol and boric acid was found to release salvianolic acid B effectively, reducing excessive scar formation and enhancing tissue regeneration during early-stage wound healing.

This review examines the mechanisms, recent findings, and strategies to enhance mesenchymal stem cells' therapeutic effects in skin wound healing, but reports no new research results.

This review discusses current findings in regenerative dermatology, noting promising results for therapies using exosomes and polynucleotides in skin rejuvenation and healing, while highlighting the need for more standardized protocols and long-term studies to confirm their effectiveness and safety.

This study reviewed 80 preclinical and clinical studies and found that exosome-mediated treatments show promise for hair regeneration in alopecia by boosting hair density and thickness with generally mild side effects, but call for further research and standardization before widespread clinical use.

This systematic literature review found that exosome and PRP therapies show promise as effective, minimally invasive options for treating androgenetic alopecia, with clinical benefits potentially superior to or complementary to minoxidil, although standardization and larger clinical trials are needed to confirm long-term safety and efficacy.

This review provides a comprehensive look at injectable treatments like PRP, stem cells, and exosomes for hair regrowth, highlighting their potential to minimize systemic and localized side effects associated with conventional medications, and improve patient care by stimulating natural hair growth.

This study found that slow vitrification using DMSO for cryopreserving hair follicle germs in mouse skin showed effective hair regeneration, making it a promising method for hair regenerative medicine.

In this study, embryonic skin fibroblasts from day E17.5 and postnatal day P5, but not E14.5, effectively supported hair follicle formation, indicating distinct developmental states and differentiation capacities.

This study found that cyclosporine A treatment at 5 mg/kg/day may reduce inflammation and promote gland regeneration in dogs with sebaceous adenitis, though symptoms returned when treatment stopped.

In this study, an injectable hydrogel incorporating antibacterial agents was shown to effectively heal wounds and promote hair follicle and capillary regeneration, offering a promising approach for skin tissue engineering.

In this study, topical sildenafil citrate was found to improve hair regeneration in a rat model of androgenic alopecia, showing superior long-term effects compared to minoxidil, including increased hair follicle numbers and epidermal thickness.

This study reports that a new ROS-responsive hydrogel platform delivering miR-665 effectively reduced inflammation and promoted hair follicle regeneration in AA, suggesting a promising treatment approach.

In this study, cinnamaldehyde loaded onto gypsum-calcium carbonate scaffolds showed promise in promoting early-stage bone healing in rats but was less effective at later stages, with better results when combined with dehydrothermal treatment.

This study found that fermentation products from Bacillus sp. TC5 can effectively promote hair regrowth and improve transdermal drug absorption, suggesting their potential as eco-friendly agents in developing cosmeceuticals for hair restoration and skin repair.

In this study, researchers compared several commercial products for facial skin repair and found that only the product containing exosomes purified from bovine colostrum showed positive effects on cell proliferation, viability, and wound repair in vitro, outperforming untreated samples and other tested products.

In this study, subcutaneous injection of mesenchymal stem cell-conditioned medium promoted regeneration of mice skin aged by D-galactose, improving skin thickness, vascularization, and collagen density.

This review discusses various aesthetic and regenerative applications of platelet-rich plasma and concludes that it has potential as a safe cosmetic intervention but requires further studies to understand its clinical effects.

This review covers advancements in skin repair and rejuvenation technologies, highlighting potential benefits of stem cell therapy, bioengineered skin substitutes, PRP, exosome therapies, and gene editing for conditions such as chronic wounds and genetic disorders, though challenges in accessibility, safety, and long-term effectiveness remain.

In this study, RT1640 was found to promote hair pigment system regeneration and expand melanocyte stem cell pools in a mouse model, suggesting potential applications for aging-related hair disorders.

This review highlights that stem cell-based therapies show promise in skin regeneration for conditions like chronic wounds and burns due to their regenerative and immunomodulatory effects, though challenges like safety and scalability limit widespread clinical use.

This study found that a biomaterial gel made from human hair keratins facilitated nerve regeneration in an animal model, potentially matching the effectiveness of traditional autografts.

In this study, Japanese patients treated with adipose-derived stem cell-conditioned medium for hair regeneration showed positive outcomes, suggesting it may be an effective new therapy for alopecia.

This study found that hair follicle stem cells can effectively enhance nerve regeneration and restore function in peripheral nerve injuries in mice, suggesting their potential as a source for autologous stem cell therapy.

This study introduces a novel chitosan-based hydrogel containing cinnamaldehyde-tannic acid-zinc acetate nanospheres, which reportedly enhances wound healing by promoting antibacterial, antioxidant, and anti-inflammatory effects.

This review discusses the potential and limitations of adipose-derived stem cells and their conditioned medium for hair regeneration, highlighting novel preconditioning methods to enhance their effectiveness, without presenting new clinical results.

This review found that while preclinical studies highlight the potential benefits of exosome therapeutics for hair loss, clinical evidence on their safety and effectiveness for alopecia is currently lacking, requiring further research.

This review discusses how functionalized hydrogels can modulate the microbiome to aid tissue regeneration and infection control, highlighting their potential to deliver therapeutic agents effectively and support beneficial immune responses.