Industrial Mass Production of Platelet Dry Powder

    November 2023 in “ Applied sciences ”
    Shih-Chieh Lin, Chen‐Ying Su, Hsu‐Wei Fang
    TLDR Pig blood can be used to mass-produce stable, low-cost platelet dry powder for medical use.
    The study developed a method for industrial mass production of platelet dry powder from pig blood, achieving a platelet concentration 15 times higher than whole blood using calcium chloride as an activator. Different calcium chloride concentrations affected growth factor levels, with 20% yielding the highest TGF-β1 and 10% the highest PDGF-BB. The powder maintained over 90% of its initial TGF-β1 concentration after 12 months, demonstrating long-term stability. The method is cost-effective, environmentally friendly, and offers a reliable supply for regenerative medicine and tissue engineering. The process showed high reproducibility across six batches, confirming its stability and repeatability.
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