TLDR Ozone and procaine boost the release of healing factors in platelet-rich plasma.
This study explored the effects of ozone and procaine on platelet-rich plasma (PRP) to enhance its regenerative properties. Using transmission electron microscopy and bioanalytical assays, researchers found that both agents induced significant morpho-functional changes in platelets, leading to an increased release of bioactive factors. Ozone treatment resulted in increased surface protrusions and α-granule release, while procaine treatment led to a higher release of microvesicles. Nine out of thirteen analyzed platelet-derived factors significantly increased after treatment, indicating that ozone and procaine can enhance PRP's therapeutic potential without damaging the platelets.
848 citations
,
October 2020 in “International Journal of Molecular Sciences” The document reviewed the potential of platelet-rich plasma (PRP) as an adjunctive therapy in regenerative medicine, particularly for musculoskeletal and spinal disorders, osteoarthritis, and chronic wounds. It highlighted the challenges in translating in vitro and animal study outcomes to human clinical treatments. Recent advancements in PRP technology were discussed, focusing on platelet dosing, leukocyte activities, and serotonin effects, as well as PRP's role in inflammation and angiogenesis. The review also examined the impact of drugs on PRP activity and the integration of PRP with rehabilitation protocols.
348 citations
,
July 2017 in “Skin appendage disorders” Platelet-rich plasma shows promise for skin and hair treatments but needs more research and standardization.
January 2017 in “Springer eBooks” The document explains various skin conditions and their treatments.
93 citations
,
February 2008 in “Atmospheric environment” Ozone reacts more with unwashed hair, producing compounds due to scalp oils, which could lower ozone exposure but increase exposure to reaction products.
25 citations
,
February 2017 in “Anticancer Research/Anticancer research” Ozone therapy might improve cancer treatment and reduce its side effects.
January 2020 in “Acta Scientiae Veterinariae” A dog's chronic bite wound healed successfully using a mix of herbal gel, low power laser, and ozone therapy.
2 citations
,
June 1983 in “Proc., Annu. Meet., Air Pollut. Control Assoc.; (United States)”
