Ozone and Procaine Increase Secretion of Platelet-Derived Factors in Platelet-Rich Plasma
October 2023
in “
European journal of histochemistry
”
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Studysummary This study demonstrated that treating platelet-rich plasma with ozone or procaine in vitro led to distinct changes in platelet activity, significantly enhancing the release of platelet-derived factors without damaging the platelets, indicating potential for improved regenerative therapies.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This study explored the effects of ozone and procaine on platelet-rich plasma (PRP) to enhance its regenerative properties. Using transmission electron microscopy and bioanalytical assays, researchers found that both agents induced significant morpho-functional changes in platelets, leading to an increased release of bioactive factors. Ozone treatment resulted in increased surface protrusions and α-granule release, while procaine treatment led to a higher release of microvesicles. Nine out of thirteen analyzed platelet-derived factors significantly increased after treatment, indicating that ozone and procaine can enhance PRP's therapeutic potential without damaging the platelets.
