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Key enzymes control androgen levels, affecting hormone activity and potential treatments.

Finasteride effectively blocks rat enzymes, but with varying methods and strength.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

Finasteride modifies 5-alpha-reductases through a two-step process, affecting inhibitor potency and possibly causing side effects.

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

GI198745 is more potent and longer-lasting than finasteride, potentially better for treating hair loss.

Pumpkin seed products may help improve prostate and bladder health by blocking certain enzymes and hormone receptors.

New compounds were made that effectively block enzymes related to prostate issues and hair loss.

The research gives new understanding on how human steroid 5α-reductases work and how drugs like finasteride inhibit them, which could help in creating new drugs.

A gene in Sebekia benihana, CYP-sb21, is needed for a specific reaction on the drug Cyclosporine A, which could be important for hair growth without affecting the immune system.

RE-ORGA, a Korean herb extract, may help prevent hair loss.

Human hair color is influenced by complex biochemical processes involving enzymes and reactive oxygen species.

The research helps understand how finasteride works and aids drug development.

LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.

Finasteride, a drug that changes testosterone to a different hormone, was studied and its effects over time were modeled successfully.

Prostate cancer was a major health issue in 2009, especially for Black men, and targeting the 5alpha-reductase enzyme could help in its prevention and treatment.

New drug dutasteride effectively treats hair loss, but use cautiously due to potential sexual side effects.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

Fadrozole and Finasteride change frog sex ratios and cause intersex animals with altered gene expressions.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

Steroids, particularly estrogens and 5α-reductase inhibitors, affect blood vessel-related hair growth processes in hair follicle cells.

Some hair loss and prostate drugs might increase the risk of diabetes and heart disease.

Natural herbal compounds might treat certain medical conditions by reducing DHT levels, but more research is needed to confirm their effectiveness and safety.

Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.

5α-Reductase inhibitors do not consistently increase testosterone levels in the blood.

Scientists made a carbon-14 labeled version of a drug with a 48% yield and over 99% purity.

Reducing 5α-reductase activity helps endometrial cells differentiate, aiding pregnancy.

The document concludes that the risk of sexual side effects from 5-alpha-reductase inhibitors is low and often temporary, but more research is needed on potential permanent effects.