The Redox Biochemistry of Human Hair Pigmentation

    October 2010 in “ Pigment cell & melanoma research ”
    Karin U. Schallreuter, Mohamed M. A. E. L. Salem, Sybille Hasse, Hartmut Rokos
    TLDR Human hair color is influenced by complex biochemical processes involving enzymes and reactive oxygen species.
    The document discussed the complex biochemistry of human hair pigmentation, focusing on the role of the hair follicle melanocyte and the enzyme tyrosinase in melanin formation. It highlighted the importance of understanding various factors such as enzyme kinetics, substrate supply, pH levels, and cAMP signaling in the pigmentation process. The study also emphasized the impact of reactive oxygen species on enzyme regulation and the significance of methionine sulfoxide repair via methionine sulfoxide reductases A and B (MSRA and B). The research primarily relied on data from the C57BL/6 mouse model, and it remained uncertain whether these findings could be directly applied to humans.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 1000+ results

      community Is there any new drug that looks promising ?

      in Research/Science  25 upvotes 8 months ago
      The conversation discusses GT20029, a drug in Phase II trials that targets androgen receptors with minimal systemic effects, and TDM-105795, a growth stimulant with a different mechanism than minoxidil that may revive papilla stem cells. Both are potential new treatments for hair loss.

      community How all hormones affect our hair follicles. Not just DHT. Take a look at this paper. Prolactin, melatonin, cortisol, progesterone, testosterone and more

      in Research/Science  126 upvotes 2 years ago
      The conversation discusses various factors affecting hair loss, not just DHT, and mentions treatments like Minoxidil, finasteride, and melatonin. Some users report personal experiences with these treatments and hormone tests, while others speculate on the role of hormones like prolactin and cortisol in hair loss.

      community Please explain this Minoxidil phenomena

      in Minoxidil  60 upvotes 1 year ago
      The post discusses the difference in effects of Minoxidil (Min) on scalp and facial hair. The user questions why Min-induced hair growth on the scalp is temporary, while facial hair growth seems permanent, even after stopping Min. They propose theories, including different Min mechanisms on body and facial hair, the role of DHT, and the possibility of not achieving fully terminal hair. The responses include personal experiences and theories about Min's effects on hair growth.

      community Hair follicle cloning is already possible

      in Chat  38 upvotes 1 month ago
      Hair follicle cloning is claimed to be possible but not widely available due to potential safety issues, such as cancer risks. Current treatments like finasteride and dutasteride are not effective for everyone, and there is frustration over limited access to these medications.

    Related Research

    3 / 3 results