TLDR Human hair color is influenced by complex biochemical processes involving enzymes and reactive oxygen species.
The document discussed the complex biochemistry of human hair pigmentation, focusing on the role of the hair follicle melanocyte and the enzyme tyrosinase in melanin formation. It highlighted the importance of understanding various factors such as enzyme kinetics, substrate supply, pH levels, and cAMP signaling in the pigmentation process. The study also emphasized the impact of reactive oxygen species on enzyme regulation and the significance of methionine sulfoxide repair via methionine sulfoxide reductases A and B (MSRA and B). The research primarily relied on data from the C57BL/6 mouse model, and it remained uncertain whether these findings could be directly applied to humans.
217 citations
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February 2009 in “The FASEB Journal” Gray hair is caused by hydrogen peroxide buildup, which damages hair color repair.
210 citations
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May 2006 in “The FASEB journal” Oxidative stress causes hair to gray by damaging and killing pigment cells.
65 citations
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May 2006 in “Journal of Investigative Dermatology” Dexamethasone may influence hair growth by altering estrogen receptor activity in hair cells.
450 citations
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January 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair color is determined by melanin produced and transferred in hair follicles.
192 citations
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October 1998 in “Experimental Dermatology” Androgenetic alopecia involves complex hair follicle changes and knowledge gaps remain.
210 citations
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July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair color production in mice is closely linked to the hair growth phase and may also influence hair growth itself.
44 citations
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April 1979 in “Journal of Ultrastructure Research”
1 citations
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January 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” Increased PHGDH expression causes early melanin buildup in hair follicles.
240 citations
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April 2011 in “Pigment Cell & Melanoma Research” Melanocyte stem cells in hair follicles are key for hair color and could help treat greying and pigment disorders.
17 citations
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October 2010 in “Pigment cell & melanoma research” Human hair color is influenced by complex biochemical processes involving enzymes and reactive oxygen species.
86 citations
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August 2000 in “Pigment cell research” Melanocyte activity in hair follicles is linked to the hair growth cycle, being active in growth phases and inactive in rest phases.
