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      research Gene Expression Profiles of Melanocytes Over-Expressing miR-5110 in Alpaca

      January 2026 in “Current Issues in Molecular Biology”
      This study investigated the molecular mechanisms of pigmentation in alpaca melanocytes over-expressing miR-5110. Using high-throughput RNA sequencing, researchers identified 91,976 unigenes, with 13,262 exceeding 2000 nucleotides. Key pathways related to melanogenesis, including MAPK, Wnt, and cAMP signaling, were identified. Compared to controls, 162 genes were upregulated and 41 downregulated in miR-5110 over-expressed melanocytes. Differential expressions of genes such as DKK3, Pmel, IGF1R, CDK5, Ednrb, Kitl, Myc, and S100 were confirmed via qRT-PCR. Notably, Kitl and MAPKAPK3 emerged as candidate genes for miR-5110-regulated melanogenesis, offering new insights into pigmentation processes.
      Molecular Regulation of Melanocyte Senescence

      research Molecular Regulation of Melanocyte Senescence

      85 citations , July 2002 in “Pigment Cell Research”
      The article concludes that while we understand a lot about how melanocytes age and how this can prevent cancer, there are still unanswered questions about certain pathways and genes involved.
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      community I think this is my stop, gentlepeople. So long and thanks for all the data 👋

      in Transgender  2260 upvotes 8 months ago
      A user shared their successful experience with hair regrowth and transitioning from male to female using minoxidil, finasteride, Nutrafol, microneedling, and hormone replacement therapy (HRT). They expressed gratitude for the results and encouraged others to explore treatments that align with their personal goals.

      community Ultimate Stack without nuking your gender (you'll go broke)

      in Treatment  82 upvotes 1 year ago
      A hair loss treatment plan includes finasteride, dutasteride, RU58841, pyrilutamide, minoxidil, and microneedling to inhibit DHT and promote hair growth. It also recommends supplements like Reishi and Lion’s Mane mushrooms, and a shampoo with ketoconazole, caffeine, and melatonin.

      community I feel like people here shrug off nutritional issues too quickly. Particularly for Retrograde Alopecia.

      in Chat  9 upvotes 3 years ago
      The user believes Retrograde Alopecia may be linked to vitamin imbalances, specifically from taking too much Vitamin E, A, Zinc, and Selenium, and suggests it could be a middle ground between Androgenic Alopecia and Telogen Effluvium. Treatments for hair loss mentioned include Androgen inhibitors and improving lifestyle factors like nutrition and sleep, with topical melatonin also recommended for Retrograde Alopecia.

      community 5ARI (dutasteride) Associated with Adverse Metabolic Effects

       24 upvotes 7 years ago
      Dutasteride is associated with increased blood glucose, HbA1c, LDL cholesterol, and liver enzyme activity, potentially leading to diabetes, NAFLD, and liver metabolism changes. The conversation highlights concerns about these adverse effects and calls for more studies, including on finasteride.

      community Gains or growth? Three months in

      in Is this regrowth?  146 upvotes 10 months ago
      The user is using topical minoxidil twice daily for hair regrowth and is hesitant to use finasteride due to concerns about hormonal effects. The conversation includes mixed opinions on the effectiveness of the treatment and suggestions to use a DHT blocker for better results.
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