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Glossary Aldo-Keto Reductase Family 1 Member C3

enzyme involved in hormone metabolism affecting hair growth and alopecia

Aldo-Keto Reductase Family 1 Member C3 (AKR1C3) is an enzyme that plays a crucial role in the metabolism of steroids, prostaglandins, and other compounds. It is involved in the conversion of hormones like testosterone and estrogen, which can influence various physiological processes, including hair growth and the development of conditions like alopecia.

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5 / 343 results

Unraveling the Link Between Insulin Resistance and Androgen Excess

research Unravelling the link between insulin resistance and androgen excess

December 2015 in “University of Birmingham Institutional Research Archive (University of Birmingham)”

This study showed that regulation of adipose androgen generation via AKR1C3 may contribute to a cycle of hyperinsulinaemia and lipid accumulation in women with PCOS.

research Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review

70 citations , September 2017 in “Expert opinion on therapeutic patents”

This review examines the patent literature on AKR1C3 inhibitors and suggests that although numerous potent inhibitors exist, further preclinical optimization is necessary before assessing their therapeutic potential in human diseases.

Cloning, Computational Analysis and Expression Profiling of Steroid 5 Alpha-Reductase 1 (SRD5A1) Gene During Reproductive Phases and Ovatide Stimulation in Endangered Catfish, Clarias Magur

research Cloning, computational analysis and expression profiling of steroid 5 alpha-reductase 1 (SRD5A1) gene during reproductive phases and ovatide stimulation in endangered catfish, Clarias magur

November 2023 in “Scientific reports”

This study presents the first report on cloning and characterizing the full-length cDNA of SRD5A1 in Indian catfish (Clarias magur), revealing expression differences across reproductive phases and increased expression post-Ovatide administration in ovaries and testis.

research Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases

11 citations , February 2016 in “Current Medicinal Chemistry”

This review discusses various targets for treating prostate cancer and benign prostatic hyperplasia and reports on recent studies of new compounds and 5α-reductase inhibitors, but provides no new experimental results.

research Inhibition of Human Steroid 5β-Reductase (AKR1D1) by Finasteride and Structure of the Enzyme-Inhibitor Complex

47 citations , June 2009 in “Journal of Biological Chemistry”

This study found that finasteride competitively inhibits the enzyme AKR1D1 with low micromolar affinity but does not act as a mechanism-based inactivator.

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Community Join

2 / 1000+ results

community My Idea for a possible new hairloss treatment

53 upvotes 6 years ago

Exploring a potential hair loss treatment using the enzyme AKR1C2 to locally reduce DHT levels. Challenges include enzyme delivery through the skin and high production costs, with gene therapy or stem cells suggested as future alternatives.

community Switched from finasteride to dutasteride - 2 month update

in Finasteride/Dutasteride 6 upvotes 2 years ago

The user switched from finasteride to dutasteride for hair loss treatment, but experienced increased libido, itchy scalp, and accelerated hair loss. Another user suggested that genetic variations might cause dutasteride to be less effective and recommended checking for specific genetic markers.

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