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This study found that Puerariae Flos extract inhibited testosterone 5α-reductase and promoted hair growth in mouse models, suggesting its potential use for treating androgenic alopecia.

This article reviews treatment options for androgenetic alopecia, highlighting potential uses of plant materials, but reports no new clinical results.

In this study, researchers developed a novel platform for discovering potential hair loss inhibitors by investigating the testosterone/dihydrotestosterone biosynthetic pathway and its regulation through biochemical mechanisms involving 17β-HSD and 3β-HSD, combined with medicinal plant extracts.

This study found that topical Rosmarinus officinalis leaf extract improved hair regrowth in mice and inhibited androgen-associated mechanisms involved in hair loss.

This study found that Phyllanthus urinaria extract displayed significant anti-alopecia properties in a mouse model, showing potential as an anti-5α-reductase agent for androgenic hair loss.

This review discusses current therapeutic targets and treatments for androgenic alopecia but reports no clinical results; the authors highlight the challenge of developing multi-target drugs for effective treatment.

This review discusses various plants and herbal formulations traditionally used for hair growth and notes their potential as safer alternatives to synthetic hair loss treatments, but reports no new clinical results.

This review summarizes preclinical and clinical information on herbal products for hair loss treatment, highlighting their mechanisms, follicular penetration, and potential side effects, suggesting they may offer alternatives to synthetic drugs with fewer side effects.

This study found that Cacumen platycladi extract significantly promoted hair growth and reduced dihydrotestosterone levels by inhibiting 5α-reductase activity in an androgen-sensitive mouse model.

This study suggests that icariin promotes hair follicle growth in mice by enhancing IGF-1 expression in dermal papilla cells.

This study found that the methanolic heartwood extract of Avicennia marina significantly inhibits 5α-reductase type 1, reducing 5α-DHT production by 52% in a cell-based assay with human hair dermal papilla cells.

This study found that Avicennia marina extract significantly inhibited 5α-reductase type 1 activity in human hair dermal papilla cells, suggesting its potential use for treating androgenic alopecia.

This study reviews existing literature on botanicals for androgenetic alopecia, noting a growing interest and emphasizing research on hair growth stimulants, especially involving green tea and other specific botanicals.

This review highlights the challenges in screening for steroid 5 alpha-reductase inhibitors and discusses significant variability in the effectiveness of finasteride and dutasteride, calling for standardized testing methods to develop safer, more specific inhibitors from herbal preparations.

This study investigated the effects of the herbal formulation DA-5512 on hair growth, finding that it significantly promotes dermal papilla cell proliferation and stimulates hair growth in mice while showing efficacy and safety in human trials compared to placebo and minoxidil (3%).

This review assessed experimental studies on herbs used for alopecia, identifying potential mechanisms involving hair cycle management and keratinocyte processes, but highlighted a need for improved evidence on quality control and toxicity of these herbal treatments.

This study reported that the n-butanol fraction of Perilla frutescens extract, particularly rosmarinic acid, showed potential for hair regrowth and anti-androgenic activity in male mice, suggesting it as a possible treatment for androgenetic alopecia.

This review evaluates laboratory models used in androgenetic alopecia research but reports no new findings, emphasizing the potential of human-derived 3-D models for future studies.

This study suggests that while complementary and alternative treatments for hair loss are becoming more popular, their effectiveness and mechanisms remain largely unverified.

This chapter provides an overview of phytochemicals with properties to combat alopecia and discusses the potential of flavonoids, found in several herbs, as a safer alternative to synthetic hair loss treatments due to their long-term skin compatibility.

This study found that Avicennia marina extract and its active compound avicequinone C inhibit enzymes and receptors related to androgenic alopecia, potentially supporting hair growth in cultured dermal papilla cells.

This review discusses potential cosmeceutical treatments for hair loss, including ingredients like procyanidins and isoflavones, but does not present new clinical outcomes; the authors highlight the promise of further research.

This meta-analysis found that traditional Chinese medicine may be an effective and safe adjuvant therapy for androgenetic alopecia, improving efficacy rates and symptom scores compared to conventional medicine.

This review examines around 68 plant sources from six major plant families, assessing their scientific rationale and use by the cosmeceutical industry for applications like anti-ageing and sun protection.

This review reports that natural compounds show promise in slowing skin photoaging by targeting cellular pathways in keratinocytes and fibroblasts. However, comprehensive clinical studies are needed to verify their efficacy and safety.

This study found that caffeic acid amide derivative, compound 4, effectively inhibited steroid 5α-reductase type 1 in vitro, suggesting potential for development as a treatment for androgenic alopecia.

This study found that Physcion from Polygonum multiflorum may be an effective natural 5α-reductase inhibitor for treating androgenic alopecia by enhancing hair growth and improving follicle morphology in laboratory settings.

This study found that tectoridin, an isoflavone from Rhizoma Belamcandae, may stimulate hair growth by activating Wnt signaling in human and mouse cell cultures.

This review examines the anti-alopecia effects of plant-derived phytochemicals and their mechanisms for promoting hair growth, but it reports no new clinical findings.

This study found that AiQingHua oil improved microcirculation and promoted hair regeneration in mice with testosterone-induced alopecia.