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Did you mean Protein-Protein Interaction?

GlossaryProtein-Protein Interaction Network

complex web of interactions between different proteins within cells

A Protein-Protein Interaction Network (PPI Network) is a complex web of interactions between different proteins within a cell. These interactions are crucial for various biological processes, such as cell signaling, metabolism, and structural organization. Understanding PPI Networks helps scientists identify how proteins work together to maintain cellular functions and can provide insights into diseases like alopecia, where these interactions may be disrupted.

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research Computational Drug Discovery in Chemotherapy-Induced Alopecia via Text Mining and Biomedical Databases

3 citations, April 2019 in “Clinical Therapeutics”

Computational tools identified 29 drugs that could potentially target 19 genes involved in chemotherapy-induced hair loss, which could lead to more effective treatments.

research Analysis of Protein Interactions by Surface Plasmon Resonance

42 citations, September 2017 in “Advances in protein chemistry and structural biology”

Surface Plasmon Resonance is a useful tool for studying protein interactions and has potential for future technological advancements.

research Comparative Proteomic Analysis in Scar-Free Skin Regeneration in Acomys Cahirinus and Scarring Mus Musculus

13 citations, January 2020 in “Scientific Reports”

The African spiny mouse heals skin without scarring due to different protein activity compared to the common house mouse, which heals with scarring.

A Disease-Causing Novel Missense Mutation in the ST14 Gene Underlies Autosomal Recessive Ichthyosis with Hypotrichosis Syndrome in a Consanguineous Family

research A Disease-Causing Novel Missense Mutation in the ST14 Gene Underlies Autosomal Recessive Ichthyosis with Hypotrichosis Syndrome in a Consanguineous Family

9 citations, March 2018 in “European journal of dermatology/EJD. European journal of dermatology”

A new mutation in the ST14 gene causes a rare skin and hair disorder in a specific family.

Melatonin Promotes Cashmere Goat (Capra Hircus) Secondary Hair Follicle Growth: A View from Integrated Analysis of Long Non-Coding and Coding RNAs

research Melatonin Promotes Cashmere Goat (Capra Hircus) Secondary Hair Follicle Growth: A View from Integrated Analysis of Long Non-Coding and Coding RNAs

32 citations, May 2018 in “Cell Cycle”

Melatonin helps Cashmere goats grow more hair by affecting certain genes and cell pathways.

Proteomic Identification and Quantification of Secretory Proteins in Human Dermal Fibroblast-Conditioned Medium for Wound Repair and Hair Regeneration

research Proteomic Identification and Quantification of Secretory Proteins in Human Dermal Fibroblast-Conditioned Medium for Wound Repair and Hair Regeneration

May 2023 in “Clinical, Cosmetic and Investigational Dermatology”

The research found proteins in human skin cells that help with wound healing and hair growth, which could lead to new treatments.

research Identification of Key Genes and Signaling Pathways in Male Androgenetic Alopecia by Bioinformatics Analysis

July 2020 in “Bioinformatics and Bioengineering”

Found key genes affecting hair loss, immune response, and skin development; more research needed for better treatments.

Transcriptome Analysis Reveals an Inhibitory Effect of Dihydrotestosterone-Treated 2D- and 3D-Cultured Dermal Papilla Cells on Hair Follicle Growth

research Transcriptome Analysis Reveals an Inhibitory Effect of Dihydrotestosterone-Treated 2D- and 3D-Cultured Dermal Papilla Cells on Hair Follicle Growth

5 citations, September 2021 in “Frontiers in Cell and Developmental Biology”

Dihydrotestosterone treatment on 2D and 3D-cultured skin cells slows down hair growth by affecting certain genes and could be a potential target for hair loss treatment.

research ST14 Interacts With TMEFF1 and Is a Predictor of Poor Prognosis in Ovarian Cancer

March 2024 in “BMC cancer”

High levels of ST14 and TMEFF1 proteins in ovarian cancer are linked to worse patient outcomes and may be a new treatment target.

research Short-Term Responses of Soybean Roots to Individual and Combinatorial Effects of Elevated CO2 and Water Deficit

16 citations, December 2018 in “Plant Science”

Elevated CO2 can lessen the negative impact of water shortage on soybean roots and affects specific genes.

research Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men

139 citations, December 2020 in “Cell Stem Cell”

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

research Transcriptome Reveals Long Non-Coding RNAs and mRNAs Involved in Primary Wool Follicle Induction in Carpet Sheep Fetal Skin

37 citations, May 2018 in “Frontiers in physiology”

Certain RNA molecules are important for the development of wool follicles in sheep.

research Discovery of a Transdermally Deliverable Pentapeptide for Activating AdipoR1 to Promote Hair Growth

8 citations, September 2021 in “EMBO Molecular Medicine”

A new small peptide may help hair growth by activating a specific receptor and should be tested in humans.

research Efficacy and Mechanism of Topical Shen Bai Hair Growing Decoction Against Androgenetic Alopecia

February 2024 in “ACS Omega”

The Shen Bai Hair Growing Decoction may help treat hair loss by promoting hair growth and reducing inflammation.

research Inhibition of Mitochondrial Respiration Prevents BRAF-Mutant Melanoma Brain Metastasis

29 citations, April 2019 in “Acta neuropathologica communications”

Stopping mitochondrial respiration can prevent brain cancer spread in skin cancer patients, and plant compound β-sitosterol could help achieve this.

research The 1,25-Dihydroxyvitamin D3-Independent Actions of the Vitamin D Receptor in Skin

18 citations, July 2010 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

The vitamin D receptor helps regulate skin and hair health independently of its usual vitamin D ligand.

research Genomic and Transcriptomic Characterization of Atypical Recurrent Flank Alopecia in the Cesky Fousek

2 citations, April 2022 in “Genes”

The study found that the hair loss condition in Cesky Fousek dogs is influenced by multiple genes affecting skin and muscle structure, fat metabolism, and immunity.

research MiR-199a-3p Regulates the PTPRF/β-Catenin Axis in Hair Follicle Development: Insights into the Pathogenic Mechanism of Alopecia Areata

1 citations, December 2023 in “International journal of molecular sciences”

miR-199a-3p controls hair growth and is linked to alopecia areata.

research Elucidating the Anti-Aging Mechanism of Si Jun Zi Tang by Integrating Network Pharmacology and Experimental Validation In Vivo

6 citations, May 2022 in “Aging”

Si Jun Zi Tang may slow aging by affecting specific cell signaling pathways.

Bioinformatic Analysis of Gene Expression Data Reveals Src Family Protein Tyrosine Kinases as Key Players in Androgenetic Alopecia

research Bioinformatic Analysis of Gene Expression Data Reveals Src Family Protein Tyrosine Kinases as Key Players in Androgenetic Alopecia

June 2023 in “Frontiers in Medicine”

Protein tyrosine kinases are key in male pattern baldness, affecting skin structure, hair growth, and immune responses.

research Integration Analysis of Hair Follicle Transcriptome and Proteome Reveals the Mechanisms Regulating Wool Fiber Diameter in Angora Rabbits

March 2024 in “International journal of molecular sciences”

The research identified key proteins that affect wool fiber thickness in Angora rabbits.

research Identification of the Key Proteins Associated With Different Hair Types in Sheep and Goats

2 citations, September 2022 in “Frontiers in genetics”

Different proteins are linked to the varying thickness of sheep and goat hair types.

research Identification of Immune Microenvironment Changes, Immune-Related Pathways and Genes in Male Androgenetic Alopecia

September 2023 in “Medicine”

The research suggests immune system changes and specific gene expression may contribute to male hair loss, proposing potential new treatments.

research Cutaneous Transcriptome Analysis in NIH Hairless Mice

7 citations, August 2017 in “PloS one”

Key genes linked to hair growth and cancer were identified in hairless mice.

research Hair Follicle Transcriptome Analysis Reveals Genes Regulating Wool Fiber Diameter in Angora Rabbits

3 citations, March 2023 in “Biology”

Genes affecting wool fiber thickness in Angora rabbits were identified, which could help breed finer wool.

Label-Free Proteomics to Identify Keratins and Keratin-Associated Proteins and Their Effects on the Fleece Traits of Inner Mongolia Cashmere Goats

research Label-Free Proteomics to Identify Keratins and Keratin-Associated Proteins and Their Effects on the Fleece Traits of Inner Mongolia Cashmere Goats

January 2023 in “Czech Journal of Animal Science”

Proteins influence the quality and traits of cashmere goat fleece, affecting hair strength and diameter.