CCDC22 and CCDC93, Two Potential Retriever-Interacting Proteins, Are Required for Root and Root Hair Growth in Arabidopsis

This study identifies CCDC22 and CCDC93 as essential proteins for root and root hair growth in Arabidopsis, similar to their role in human retriever function. Phylogenetic analysis shows these genes are single copy in angiosperms but absent in grasses. Both proteins localize to the cytoplasm in root epidermal cells and are necessary for proper root development. The research also reveals a genetic interaction between CCDC93 and the VTI13-dependent trafficking pathway, with the ccdc93 mutant suppressing the vti13 root hair phenotype, highlighting the importance of endosomal pathways in plant growth.