Computational Drug Discovery in Chemotherapy-Induced Alopecia via Text Mining and Biomedical Databases

    April 2019 in “ Clinical Therapeutics ”
    Nanyang Zhang, Wenjian Xu, Shijie Wang … Xiaoxiao Zhang
    Studysummary This study identified 19 genes targeted by 29 potential drugs for topical treatment of chemotherapy-induced alopecia, suggesting avenues for drug repositioning in pharmaceutical research.
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    Research cited in this study 11

    1. Wound Healing Protects Against Chemotherapy-Induced Alopecia in Young Rats via Up-Regulating Interleukin-1β-Mediated Signaling Heliyon · 2017
    2. Chemotherapy-Induced Alopecia Management: Clinical Experience and Practical Advice Journal of Cosmetic Dermatology · 2017
    3. Treatment of Permanent Chemotherapy-Induced Alopecia with Low Dose Oral Minoxidil Australasian Journal of Dermatology · 2015
    4. Drug Discovery for Alopecia: Gone Today, Hair Tomorrow Expert Opinion on Drug Discovery · 2015
    5. Role for the Epidermal Growth Factor Receptor in Chemotherapy-Induced Alopecia PLoS ONE · 2013
    6. Pathobiology of Chemotherapy-Induced Hair Loss The Lancet Oncology · 2013
    7. Treatment of Chemotherapy-Induced Alopecia Dermatologic Therapy · 2011
    8. Chemotherapy-Induced Alopecia: Emotional Distress and Mitigation Strategies Seminars in Cutaneous Medicine and Surgery · 2009
    9. The Psychology of Hair Loss and Its Implications for Patient Care Clinics in Dermatology · 2001
    10. Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia ˜The œAmerican journal of pathology · 2000
    11. The Protective Role of the Immunomodulator AS101 Against Chemotherapy-Induced Alopecia: Studies on Human and Animal Models International Journal of Cancer · 1996