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Not having enough or having too much of the protein Grainyhead-like 3 leads to various developmental problems.

The we/we wal/wal mice have defects in hair growth and skin layer formation, causing hair loss, useful for understanding alopecia.

A specific group of slow-growing stem cells marked by Thy1 is crucial for skin maintenance and healing in mice.

Diabetes causes lasting cell dysfunctions, leading to serious complications even after blood sugar is controlled.

Stem cell differentiation is crucial for skin barrier maintenance and its disruption can lead to skin diseases.

An imbalance between certain immune cells is linked to a chronic skin condition and may be influenced by obesity, smoking, and autoimmune issues.

New techniques have enhanced our understanding of how stem cells function and the role of mutations in aging tissues, which may influence future cancer therapies.

Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.

Keratin gene expression helps understand different types of skin cells and their development, and should be used carefully as biological markers.

Different skin stem cells help heal wounds, with hair follicle cells becoming more important over time.

Fibroblasts, cells usually linked to tissue repair, also help regenerate various organs and their ability decreases with age. Turning adult fibroblasts back to a younger state could be a new treatment approach.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

Fat-derived stem cells, platelet-rich plasma, and biomaterials show promise for healing chronic skin wounds and improving soft tissue with few side effects.

New treatments targeting skin stem cells show promise for skin repair, anti-aging, and cancer therapy.

Use PRP and ASC-BT for hair loss and wound healing, but more research needed.

Effective PCOS treatments require targeting specific signaling pathways.

Mice with a changed Hr gene lose and regrow hair due to changes in the gene's activity.

Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

The Wnt/β-catenin pathway is important for body functions and diseases, and targeting it may treat conditions like cancer, but with safety challenges.

Ishige sinicola extract helps bone-building cells grow and mature, which could aid in treating osteoporosis.

Understanding how EDC genes are regulated can help develop better drugs for skin diseases.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

RF-based therapies might help treat hair loss.

Melatonin helps goat hair stem cells grow and maintain their ability to become different cell types.

KLF4 is important for maintaining stem cells and has potential in cancer treatment and wound healing.

The document concludes that the development of certain tumors is influenced by genetic background and that a specific gene modification can lead to tumor regression and reduced growth.

A specific enzyme is essential for proper hair follicle stem cell development and healthy skin.

Blocking a key energy pathway in human hair follicles can trigger stress responses that stop cell growth.