January 2026 in “Current Issues in Molecular Biology” This paper reviews the emerging role of FGF-7 signaling in hair regeneration, highlighting its potential as a target for new therapies despite limited clinical trial data.
9 citations
,
August 2014 in “European journal of ophthalmology” This study found that PGF 2α receptors were predominantly present in the inner root sheath of the bulb and stem of human eyelashes during the anagen phase.
February 2022 in “Research Square (Research Square)” In this study, researchers successfully expressed recombinant human FGF5 protein in Arabidopsis, finding that this protein inhibits hair regeneration both in vitro and in vivo.
June 2022 in “International Journal of Research in Dermatology” This study found that injectable platelet-rich fibrin significantly improved hair growth and patient satisfaction as a cost-effective adjuvant treatment for androgenetic alopecia.
54 citations
,
December 2014 in “Wound Repair and Regeneration” This study observed that autologous PRP and PDRN injections improved hair thickness and density in women with pattern hair loss, with combined therapy showing greater improvement in thickness than PDRN alone.
20 citations
,
December 2013 in “PTR. Phytotherapy research/Phytotherapy research” This study found that ginsenoside Rg3 up-regulates vascular endothelial growth factor expression in human dermal papilla cells and mouse hair follicles, suggesting its potential role in promoting hair growth.
154 citations
,
November 2017 in “Development” This review discusses the roles of fibroblast growth factors in tissue regeneration and repair across various organisms and tissues, but reports no new experimental findings, underscoring the need for further research.
10 citations
,
October 2015 in “Medicina Clínica (english Edition)” This review discusses the therapeutic potential and safety of bioidentical recombinant human epidermal growth factor (rhEGF) for various skin and mucosa conditions and reports no new clinical results.
19 citations
,
May 2016 in “Clinical, cosmetic and investigational dermatology” In this study, applying FGF-2-containing dalteparin/protamine nanoparticles to the scalp was associated with a significant increase in hair diameter over six months among participants with thin hair.
July 2020 in “Journal of Tissue Engineering and Reconstructive Surgery”
119 citations
,
November 2014 in “Trends in Cell Biology” This review discusses the mechanisms and pathways of FGFR signalling and its roles in development, disorders, and therapeutic targeting, but reports no new clinical results.
November 2018 in “Chin J Clin Lab Mgt (Electronic Edition)” This paper introduces Concentration Growth Factor (CGF) as a potential treatment for androgenetic alopecia, but reports no clinical findings on its effectiveness in promoting hair growth.
28 citations
,
September 2020 in “International Journal of Molecular Sciences” This study concluded that leucocyte-rich PRP has a continuous stimulatory effect on human fibroblast cells, enhancing their proliferation, migration, and impacting gene expression of the extracellular matrix and adhesion molecules.
3 citations
,
June 2025 in “Gyemyeong uidae haksulji” This review suggests that PDRN shows promise as a safe and versatile regenerative agent for wound healing and other dermatological applications, based on its dual mechanisms and clinical evidence of efficacy.
6 citations
,
October 2023 in “Animal Biotechnology” This study found that a 22-bp InDel polymorphism in the FGF7 gene was significantly associated with growth traits in goats, with genotypes ID and/or II linked to better growth compared to genotype DD, indicating its potential as a molecular marker in breeding programs.
14 citations
,
January 2016 in “Biochemical and Biophysical Research Communications” In this study, researchers found that ginsenoside Re from Panax ginseng increased hair shaft length and duration in mice, comparable to minoxidil, by modulating TGF-β signaling pathways.
19 citations
,
May 2001 in “Endocrinology” This study suggests that Mrp3 may play a role in both wound healing and the hair follicle cycle as a growth factor and/or angiogenesis factor.
17 citations
,
May 2005 in “Hair transplant forum international” This study evaluated the effectiveness of follicular units and growth factors derived from autologous platelet-rich plasma in improving hair growth and density in 23 male patients with pattern hair loss.
5 citations
,
January 2013 in “Otorhinolaryngology clinics : an international journal” This review discusses the use of platelet-rich plasma in cosmetic surgery, highlighting its expanding applications and promising potential in aesthetic treatments, but reports no new empirical findings.
Processed fat, SVF, and PRP are safe and effective for facial rejuvenation and hair growth.
34 citations
,
May 2001 in “Endocrinology” This study found that MRP3 is induced in wound edge keratinocytes during wound healing and may play a role as a growth or angiogenesis factor in this process and the hair follicle cycle.
February 2026 in “Frontiers in Pharmacology” This study found that injecting PRP gel derived from a patient's own blood may promote tissue regeneration and closure of intestinal fistulas unresponsive to conservative therapy.
1 citations
,
September 2016 in “Journal of Dermatological Science” This study found that FGF18 signaling helps protect hair follicles from radiation damage by maintaining the resting phase and supporting stem cell survival, potentially reducing radiation-induced hair loss.
23 citations
,
July 2015 in “PubMed” This review summarizes existing literature on PDGF's role in adipose-derived stem cells, highlighting PDGFRβ's functions in inhibiting white adipocyte differentiation and promoting proliferation and angiogenesis.
7 citations
,
March 2024 in “Veterinary Medicine and Science” In this study, eight dogs with naturally occurring skin wounds were treated with autologous platelet-rich fibrin therapy, which significantly promoted wound healing and tissue regeneration without using additional medications, leading to promising outcomes and minimal scarring.
November 2023 in “Indian journal of surgery” This study found that platelet-rich gel is a simple and effective non-surgical method for healing exposed skull injuries, resulting in complete healing with minimal scars and sparse hair growth in all patients.
August 2025 in “Biomolecules” This review explores the role of FGF signaling in hair follicle development and highlights its potential as a new therapeutic target for hair loss, which could surpass existing treatments in terms of efficacy and safety.
September 2022 in “Journal of The American Academy of Dermatology” This study found that PRP is most commonly used for treating androgenetic alopecia and facial rejuvenation, with no serious adverse events reported among participants.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that local PGE2 injection may prevent radiotherapy-induced hair loss by protecting hair follicle cells and promoting hair follicle self-repair.