Arabidopsis Oil Body-Expressed Oleosin-rhFGF5 Inhibits Hair Growth in Mice
February 2022
in “
Research Square (Research Square)
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Studysummary In this study, researchers successfully expressed recombinant human FGF5 protein in Arabidopsis, finding that this protein inhibits hair regeneration both in vitro and in vivo. Our plain-language summary of this paper — not a Tressless recommendation.
The study "Arabidopsis Oil Body-Expressed Oleosin-rhFGF5 Inhibits Hair Growth in Mouse" explores the potential of the fibroblast growth factor family member, FGF5, in regulating hair growth. The researchers successfully expressed the exogenous recombinant human FGF5 protein in Arabidopsis using transgenic technology. The recombinant protein, oleosin-rhFGF5, was confirmed to be stably inherited and expressed in Arabidopsis, with a target protein size of 47 kDa. The protein was found to inhibit the proliferation of hair follicle epithelial cells in a dose-dependent manner, starting at a concentration of 12.5 ng/mL. In vivo studies also confirmed the protein's ability to inhibit hair regeneration. This suggests potential clinical applications for hair growth regulation.
