Arabidopsis Oil Body-Expressed Oleosin-rhFGF5 Inhibits Hair Growth in Mice

The study "Arabidopsis Oil Body-Expressed Oleosin-rhFGF5 Inhibits Hair Growth in Mouse" explores the potential of the fibroblast growth factor family member, FGF5, in regulating hair growth. The researchers successfully expressed the exogenous recombinant human FGF5 protein in Arabidopsis using transgenic technology. The recombinant protein, oleosin-rhFGF5, was confirmed to be stably inherited and expressed in Arabidopsis, with a target protein size of 47 kDa. The protein was found to inhibit the proliferation of hair follicle epithelial cells in a dose-dependent manner, starting at a concentration of 12.5 ng/mL. In vivo studies also confirmed the protein's ability to inhibit hair regeneration. This suggests potential clinical applications for hair growth regulation.