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    Did you mean Polycomb Repressive Complex 2?
    Glossary Polycomb Repressive Complex 2

    regulates gene expression by modifying chromatin structure

    Polycomb Repressive Complex 2 (PRC2) is a group of proteins that play a crucial role in regulating gene expression by modifying chromatin, the material that makes up chromosomes. PRC2 adds a specific chemical mark to histones (proteins around which DNA is wrapped), leading to the repression of genes that are not needed at certain times or in certain cell types. This process is essential for proper development and cellular differentiation.

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    Research 30 of 169

    1. Epigenetic control of adult stem cell function Nature Reviews Molecular Cell Biology · 2016 · 179 citations
    2. Tailored chromatin modulation to promote tissue regeneration Seminars in Cell & Developmental Biology · 2019 · 10 citations
    3. Transcriptional and epigenetic mechanisms governing epidermal stem cell regulation Frontiers in Cell and Developmental Biology · 2026
    4. POLYCOMB REPRESSIVE COMPLEX 1 IS REQUIRED TO MAINTAIN STEM CELL IDENTITY AND TO PRESERVE ADULT TISSUE HOMEOSTASIS. Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · 2020
    5. 1358 PRC1 fine-tunes gene repression and activation to safeguard skin epithelium development and stem cell specification Journal of Investigative Dermatology · 2018 · 1 citations
    6. Dermal EZH2 simultaneously orchestrates dermal differentiation and epidermal proliferation during murine skin development bioRxiv (Cold Spring Harbor Laboratory) · 2020
    7. Dermal EZH2 orchestrates dermal differentiation and epidermal proliferation during murine skin development Developmental biology · 2021 · 6 citations
    8. Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage Cell stem cell · 2011 · 191 citations
    9. H2AK119ub dynamics control hair follicle stem cell quiescence Nature Communications · 2025 · 2 citations
    10. PRC 2 preserves intestinal progenitors and restricts secretory lineage commitment EMBO journal · 2016 · 75 citations
    11. EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair Genes & Development · 2011 · 354 citations
    12. Epigenetic regulation in adult stem cells and cancers Cell & Bioscience · 2013 · 20 citations
    13. Second International Symposium—Epigenetic Regulation of Skin Regeneration and Aging: From Chromatin Biology towards the Understanding of Epigenetic Basis of Skin Diseases 2017 · 2 citations
    14. Stem Cells behind the Barrier International journal of molecular sciences · 2013 · 22 citations
    15. Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease Genes & Development · 2008 · 667 citations
    16. ATP-dependent chromatin remodeling during mammalian development Development · 2016 · 182 citations
    17. A symphony of signals: the intricate role of lncRNAs in dermatological disorders Clinical and Experimental Medicine · 2025 · 1 citations
    18. The cellular basis of mechanosensory Merkel-cell innervation during development eLife · 2019 · 32 citations
    19. Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signaling PLOS genetics · 2019 · 19 citations
    20. H3K9me3 controls epidermis morphogenesis by regulating RNA Pol II dynamics at developmental promoters and enhancers Nature Communications · 2026
    21. GRHL3 binding and enhancers rearrange as epidermal keratinocytes transition between functional states PLOS Genetics · 2017 · 38 citations
    22. 1363 Hair follicle growth and pigmentation during ageing Journal of Investigative Dermatology · 2018
    23. 1361 A novel cell surface marker for hair follicle dermal cells throughout hair morphogenesis and cycling Journal of Investigative Dermatology · 2018
    24. 1362 The role of Fgf20 in establishing the hair follicle dermal condensate Journal of Investigative Dermatology · 2018
    25. 1359 Hair growth is induced by blockade of macrophage-derived oncostatin M and downstream JAK-STAT5 signaling in hair follicle stem cells Journal of Investigative Dermatology · 2018
    26. The Role of Histone Demethylases in Disease Springer eBooks · 2011 · 1 citations
    27. Epigenetic control of skin and hair regeneration after wounding Experimental Dermatology · 2014 · 36 citations
    28. Epidermal Stem Cells Are Defined by Global Histone Modifications that Are Altered by Myc-Induced Differentiation PLoS ONE · 2007 · 98 citations
    29. All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration Stem cell biology and regenerative medicine · 2018
    30. Disrupted Ectodermal Organ Morphogenesis in Mice with a Conditional Histone Deacetylase 1, 2 Deletion in the Epidermis Journal of Investigative Dermatology · 2013 · 32 citations