Search

for
Search:

Did you mean Polyamines?

Glossary Polyamines

organic compounds crucial for cell growth and function

Polyamines are organic compounds that play a crucial role in cell growth and function. They are involved in various biological processes, including DNA stabilization, protein synthesis, and cell proliferation. In the context of hair, polyamines like spermidine have been shown to promote hair growth and may help in treating conditions like alopecia.

Related Terms

Sort by

Research

30 / 509 results

research Activation of Polyamine Catabolism Profoundly Alters Tissue Polyamine Pools and Affects Hair Growth and Female Fertility in Transgenic Mice Overexpressing Spermidine/SpermineN 1-Acetyltransferase

124 citations , July 1997 in “Journal of Biological Chemistry”

This study found that overexpression of an enzyme in transgenic mice led to distorted polyamine levels, resulting in permanent hair loss and female infertility.

research Activated Polyamine Catabolism Depletes Acetyl-CoA Pools and Suppresses Prostate Tumor Growth in TRAMP Mice

91 citations , July 2004 in “Journal of Biological Chemistry”

This study found that overexpression of the enzyme SSAT in a mouse model significantly reduced prostate tumor size and progression, suggesting it could be a promising strategy against prostate cancer.

research Promotion of homology-directed DNA repair by polyamines

47 citations , January 2019 in “Nature communications”

This study found that polyamines enhance genome integrity by facilitating homologous recombination-mediated DNA repair, suggesting a novel role for polyamines beyond promoting cell growth and proliferation.

research Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue

43 citations , February 1999 in “Biochemical Journal”

This study found that transgenic mice overexpressing the SSAT gene under a metallothionein promoter suffered delayed hair loss and were highly sensitive to polyamine analogues, which led to significant liver changes and mortality.

research Inhibition of Polyamine Synthesis Alters Hair Follicle Function and Fiber Composition

42 citations , February 1996 in “Journal of Investigative Dermatology”

This study found that spermidine, a polyamine, plays an essential role in hair growth in sheep follicles, while spermine is not required for normal follicle function.

research Trypanocidal Effect of Isotretinoin through the Inhibition of Polyamine and Amino Acid Transporters in Trypanosoma cruzi

41 citations , March 2017 in “PLoS neglected tropical diseases”

This study found that isotretinoin, a drug commonly used for acne, inhibits polyamine transport in Trypanosoma cruzi, leading to trypanocidal effects, and suggests its potential as a treatment for Chagas disease without affecting mammalian cell viability.

research Polyamines and hair: a couple in search of perfection

30 citations , July 2010 in “Experimental Dermatology”

This article reviews the role of polyamines in hair follicle growth and discusses potential therapeutic applications but provides no new clinical results.

research Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites

17 citations , July 2013 in “Amino Acids”

This study found that elevated epidermal ODC activity in transgenic mice promotes skin tumor development by recruiting bulge stem cells, rather than through reactive oxygen species generation by polyamine catabolic oxidases.

research Increased Polyamine Concentrations in the Hair of Cancer Patients

14 citations , January 2001 in “Clinical chemistry”

This article discusses the potential use of hair fibers to noninvasively measure polyamine concentrations as a marker of tumor growth, but reports no new clinical findings.

research Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue

13 citations , March 1999 in “Biochemical Journal”

In this study, transgenic mice overexpressing the SSAT gene were highly sensitive to polyamine analogues, leading to severe liver changes and high mortality rates after treatment.

research Synthetic studies toward the development of novel minoxidil analogs and conjugates with polyamines

12 citations , February 2010 in “Tetrahedron Letters”

This article describes the synthesis of novel polyamine-modified minoxidil analogs and conjugates to potentially enhance minoxidil's biological activity, selectivity, and water solubility, but reports no new biological results.

research Increased hair polyamine levels in patients with alzheimer's disease

10 citations , June 2001 in “Annals of neurology”

This study reports that patients with Alzheimer's disease have increased levels of polyamines in their hair.

research Hairless and the polyamine putrescine form a negative regulatory loop in the epidermis

10 citations , August 2013 in “Experimental Dermatology”

This study found that Hairless (HR) and putrescine form a negative regulatory network that impacts epidermal homeostasis and hair follicle cycling, linked to the MYC superfamily's regulation of ODC expression.

research α‐Difluoromethylornithine, a polyamine inhibitor: its potential role in controlling hair growth and in cancer treatment and chemo‐prevention

9 citations , April 2006 in “International Journal of Dermatology”

This article reviews the potential for α-difluoromethylornithine to help control hair growth and prevent cancer, but it does not present new clinical results.

research Polyamine Oxidase Expression Is Downregulated by 17β-Estradiol via Estrogen Receptor 2 in Human MCF-7 Breast Cancer Cells

8 citations , July 2022 in “International Journal of Molecular Sciences”

This study found that in estrogen receptor-positive breast cancer cells, 17β-estradiol repressed polyamine oxidase transcription by interacting with AP-1 sites on its promoter.

research Commentary on: Hairless and the polyamine putrescine form a negative regulatory loop in the epidermis

5 citations , October 2013 in “Experimental Dermatology”

This study observed that putrescine and HR form a negative feedback mechanism affecting hair cycling, indicating a significant connection between HR, polyamines, and hair growth regulation.

research Altered polyamine profiling in the hair of patients with androgenic alopecia and alopecia areata

4 citations , August 2019 in “Journal of Dermatology”

This study found that polyamine levels in hair samples differ between androgenic alopecia and alopecia areata, suggesting potential non-invasive biomarkers to distinguish between these hair loss conditions.

research Distribution of polyamines may be altered in different scalp regions of patients with hair loss

3 citations , July 2019 in “Experimental Dermatology”

This study reported that polyamine levels, especially N-acetyl polyamines, were higher in the vertex region of the scalp than in the occipital region in patients with male and female pattern hair loss.

research Polyamine-controlled proliferation and protein biosynthesis are independent determinants of hair follicle stem cell fate

1 citations , April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

In this study, the researchers found that depleting natural polyamines or manipulating translation rates can enhance the stemness of hair follicle stem cells, while N1-acetylspermidine increases proliferation without affecting translation.

research Regulation of Hematopoietic Cell Development and Hair Growth in Mouse Models: Expression Analysis of Tudor-SN and Polyamine-Regulated Proteins

January 2013 in “Tampere University Institutional Repository (Tampere University)”

This study observed that Tudor-SN protein may play a significant role in the immune system and that polyamines can influence hair growth in a mouse model.

research The remarkable legacy of the K6/ODC mouse: mechanisms of polyamine-promoted tumorigenesis revealed

April 2026 in “Amino Acids”

This study reviews prior research using transgenic K6/ODC mice and demonstrates that elevated polyamines in epithelial cells contribute significantly to skin tumor development and progression by stimulating proliferation, altering cell signaling and chromatin remodeling, and affecting immune functionality, amongst other mechanisms.

research The RATIOnal Role of Polyamines in Epidermal Differentiation

August 2021 in “Journal of Investigative Dermatology”

In this study, Rahim et al. found that keratinocyte differentiation requires changes in polyamine ratios mediated by AMD1, suggesting that targeting polyamine availability could be useful for treating hyperproliferative skin disorders.

research 313 Different polyamine levels in the vertex and occipital hair of pattern hair loss patients

September 2019 in “Journal of Investigative Dermatology”

This study found that polyamine levels were higher in the vertex hair than in occipital hair among patients with pattern baldness, suggesting a relation to hair loss development in the scalp's vertex region.

research Abstract 2474: The mechanistic role of polyamines in DNA double-strand break repair

July 2017 in “Cancer Research”

This study found that polyamines participate in DNA double-strand break repair, primarily by enhancing the homologous recombination pathway through RAD51-mediated DNA strand exchange.

research Comparative Studies on Polyamine Levels in Plasma and Urine of Androgenic Alopecia Patients Treated with Finasteride for a Period of Three Years

January 2020 in “International Journal of Applied Biology and P”

This study found that finasteride treatment for androgenic alopecia significantly increased certain plasma polyamine levels over three years, but did not alter polyamine levels in urine.

research Evaluation of polyamide synthetic hair. A long-term clinical study.

5 citations , March 2000 in “PubMed”

This study found that hair implantation using a biocompatible polyamide fiber resulted in very satisfactory improvements with a low rate of adverse events among 196 patients.

research Relation of Skin Polyamines to the Hairless Phenotype in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase

54 citations , May 2001 in “Journal of Investigative Dermatology”

This study suggests that increased putrescine levels may disrupt normal hair follicle development in transgenic mice, leading to hair loss and altered skin structure, yet these mice appear more resistant to skin tumorigenesis.

research Construction of conductive polyimide dressings for accelerated wound healing via an interfacial compatibility optimization and polyelectrolyte complexation synergistic strategy

June 2026 in “Chemical Engineering Journal”

research Application of amber filler for production of novel polyamide composite fiber

15 citations , December 2015 in “Textile Research Journal”

This study describes the development of polyamide 6 composite fibers with amber filler, finding them suitable for use in medical textiles such as compression garments due to their biocompatibility with skin cells.

research Analysis on the Application of Polyamide (PA) materials to Replace Existing Materials in Hair Dryer Housings

April 2023 in “Highlights in Science, Engineering and Technology”

This review discusses the potential of flame retardant polyamide materials with glass fiber and graphene as a better performing alternative to acrylonitrile butadiene styrene for hair dryer housings, noting improvements in heat resistance, flame retardancy, durability, and UV resistance.