Polyamine-Controlled Proliferation and Protein Biosynthesis Are Independent Determinants of Hair Follicle Stem Cell Fate

April 2020 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

Kira Allmeroth, Kim Cs, Andrea Annibal, Andromachi Pouikli, Chacón-Martínez Ca, Christian Latza, Adam Antebi, Peter Tessarz, Sara A. Wickström, Martin S. Denzel

polyamines hair follicle stem cells HFSC N1-acetylspermidine ribosome stemness progenitor cells translation rates

TLDR Polyamines are important in deciding hair follicle stem cell behavior, affecting hair growth and loss.

The study from April 2020 investigated the role of polyamines in hair follicle stem cell (HFSC) fate decisions. It found that HFSCs had lower translation rates than progenitor cells, and that suppressing translation either by directly targeting the ribosome or depleting natural polyamines increased stemness. The study also identified N1-acetylspermidine as a new regulator of cell fate decisions, which could increase proliferation without reducing translation. This suggests that polyamines play a significant role in regulating stem cell fate decisions, with potential implications for hair growth and loss.

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