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This study suggests that activation of polyamine catabolism in K6-SSAT transgenic mice may significantly increase skin tumor development and progression to carcinomas following chemical induction.

In this study, the researchers discovered that specific polyamine depletion enhances stemness in hair follicle stem cells through a mechanism independent of mRNA translation.

This study found that overexpression of an enzyme in transgenic mice led to distorted polyamine levels, resulting in permanent hair loss and female infertility.

In this study, the researchers found that depleting natural polyamines or manipulating translation rates can enhance the stemness of hair follicle stem cells, while N1-acetylspermidine increases proliferation without affecting translation.

This study found that finasteride treatment for androgenic alopecia significantly increased certain plasma polyamine levels over three years, but did not alter polyamine levels in urine.