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Overexpressing SSAT in mice makes them highly sensitive to polyamine analogues, causing liver damage and high mortality.

Overexpression of SSAT in mice causes hair loss, liver damage, and sensitivity to polyamine analogues.

Overexpressing SSAT enzyme reduces prostate tumor growth in mice.

Increased ODC activity leads to skin tumors by recruiting stem cells, not by toxic byproducts.

MT-DADMe-ImmA can selectively kill head and neck cancer cells without harming normal cells.

Hairless protein and putrescine regulate each other, affecting hair growth and skin balance.

Polyamines are important for hair growth, but more research is needed to understand their functions and treatment potential.

Putting α-methylspermidine on mouse skin can start hair growth.

Altering SSAT affects fat metabolism and body fat in mice.

Spermidine may help reduce hair loss and deserves further testing as a treatment.

Overexpression of SSAT causes hair loss and skin issues, but reducing putrescine can help.

Excessive putrescine causes hair loss in transgenic mice by disrupting hair follicle development.

A spermidine-based supplement may help hair grow longer by keeping it in the growth phase.

Proteins like aPKC and PDGF-AA, substances like adenosine and ATP, and adipose-derived stem cells all play important roles in hair growth and health, and could potentially be used to treat hair loss and skin conditions.

N1-methylspermidine helps hair growth and reduces inflammation in hair follicles.

Spermidine injections increased wool growth rate in lambs without changing fibre thickness.

The 2015 Hair Research Congress concluded that stem cells, maraviroc, and simvastatin could potentially treat Alopecia Areata, topical minoxidil, finasteride, and steroids could treat Frontal Fibrosing Alopecia, and PTGDR2 antagonists could also treat alopecia. They also found that low-level light therapy could help with hair loss, a robotic device could assist in hair extraction, and nutrition could aid hair growth. They suggested that Alopecia Areata is an inflammatory disorder, not a single disease, indicating a need for personalized treatments.

Finasteride treatment for three years changes certain polyamine levels in the blood but not in urine.

Some minoxidil combinations can help differentiate leukemia cells without harming other cells.

Polycystic Ovary Syndrome (PCOS) is a common condition in women that can cause metabolic, reproductive, and psychological issues, and requires lifestyle changes and medication for management.

Experts recommend using evidence-based methods to diagnose and treat hirsutism, focusing on symptoms and underlying causes.

The document concludes that the exact way alcohol causes harm to fetal development is unknown, but it significantly affects nutrient transport to the fetus and a safe level of alcohol during pregnancy is not determined.

Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.

Non-binary transgender individuals need personalized hormonal treatments for better well-being and quality of life.

Plant steroid hormones show growth, health, and medicinal benefits in various organisms, including potential for treating diseases.

Prolactin may be important for skin growth and immune function.

Melatonin protects skin against UV damage by regulating various cellular processes.

Flutamide combined with an LHRH agonist effectively inhibits prostate growth, suggesting it could treat prostate cancer.

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

The document concludes that proper diagnosis and combined treatments are key for hirsutism management, and weight loss may help overweight patients.