June 2026 in “Journal of Biomedical Materials Research Part B Applied Biomaterials” This study found that a hydrogel made from human placenta-derived ECM, copper, and endothelial progenitor cells significantly enhanced pressure ulcer healing in a mouse model by improving wound closure and tissue regeneration.
3 citations
,
October 2010 in “Placenta” This study found that the ALK5 inhibitor TP0427736 inhibited TGF-β signaling in cell and mouse models, suggesting potential as a new treatment for androgenic alopecia.
4 citations
,
January 2004 in “Biological and Pharmaceutical Bulletin” In this study, AgK114 was found to be transiently induced in hamster epidermal keratinocytes following skin damage, suggesting its role in the recovery process after injury.
53 citations
,
June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” This article reviews extensive genetic polymorphisms in the keratin-associated proteins of human hair, indicating complexity but reporting no new clinical results and calls for further research on their potential impact on hair structure.
July 2026 in “Italian Journal of Anatomy and Embryology” This study found that induced pluripotent stem cells derived from human keratinocytes efficiently differentiated into cardiomyocytes, forming a homogeneous population with cardiac-specific molecular and functional properties, and demonstrated significant cardiac marker expression and spontaneous contraction capabilities over 15 days of differentiation induction.
January 2021 in “Hair therapy & transplantation” October 2022 in “Zenodo (CERN European Organization for Nuclear Research)” This study reported that combining Poly-D,L-Lactic Acid with Platelet-Rich Plasma for facial rejuvenation reduced wrinkle severity and improved skin tone and hyperpigmentation in a 45-year-old female patient.
18 citations
,
December 2010 in “Journal of analytical atomic spectrometry” This study demonstrated that using lead-doped keratin film as a calibration standard allows for accurate tracking of lead distribution along hair strands, revealing different exposure patterns among workers in a battery manufacturing factory in Thailand.
This case report highlights the successful use of platelet-rich plasma infiltration to treat vasopressin-induced bilateral foot digit gangrene in a 20-year-old female, suggesting its potential in stimulating angiogenesis and wound healing, though further research is necessary to assess its general efficacy.
July 2019 in “Ferroelectrics” The researchers reported that increasing protein content in human hair keratin/calcium alginate blend films led to larger molecular aggregates, which influenced the films' physical properties such as light transmittance and tensile strength.
54 citations
,
November 2015 in “Methods in enzymology on CD-ROM/Methods in enzymology” This chapter reviews keratins in skin epithelia, including their roles in cellular function and disease, and reports no new experimental results.
26 citations
,
February 2003 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that cutaneous pyridoxal 5'-phosphate hydrolase activity may be carried out by an enzyme different from the classical tissue-nonspecific alkaline phosphatase in human and mouse skin.
April 2017 in “Journal of Investigative Dermatology” This study identified that dominant mutations in the KLHL24 gene cause epidermolysis bullosa through dysregulated autoubiquitination, leading to excessive degradation of keratin 14.
20 citations
,
August 2015 in “International Journal of Molecular Medicine” This study found that human placental extract promoted hair growth and influenced cellular pathways in vitro and rat models, suggesting potential for future hair loss treatments.
February 2023 in “International Journal of Biological Macromolecules” This study reports that PRP-loaded bioactive fibrous hydrogels significantly enhance wound healing in diabetic foot ulcers by reducing inflammation and promoting tissue growth, with reduced administration frequency compared to standard PRP gel.
January 2005 in “Life sciences” This review discusses the pathophysiologic role of lysophosphatidic acid in the skin and reports no clinical results, suggesting pharmacological inhibition as a potential treatment for various skin disorders.
4 citations
,
December 2016 in “Blood” This study describes a case of cyclic thrombocytopenia where a novel MPL gene mutation may contribute to the disease, with gene expression changes in platelet and neutrophil genes preceding platelet count fluctuations.
6 citations
,
September 2023 in “Experimental physiology” In this study, researchers identified the PLD-mGluR protein in primary mechanosensory terminals as the homomeric GluK2 kainate receptor, functioning purely metabotropically, which is suggested to be common to various sensory endings.
1 citations
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January 2023 in “Biochemical and biophysical research communications” This study found that hepatic KRT79 expression is regulated by PPARA and is significantly associated with liver stress, suggesting it may serve as a diagnostic marker for liver diseases.
August 2026 in “Journal of Cosmetic Dermatology” This study found that Plinest injections improved skin hydration and elasticity in the face, neck, and décolleté and were well-tolerated, with high patient satisfaction over a 4-month follow-up.
13 citations
,
May 2001 in “Current problems in dermatology” Keratin proteins in epithelial cells are dynamic and crucial for cell processes and disease understanding.
August 2024 in “Quality in Sport” This review highlights the positive effects of platelet-rich plasma in aesthetic and regenerative medicine, particularly for skin rejuvenation, anti-aging, hair reconstruction, and wound healing, but it reports no new clinical results.
42 citations
,
April 2016 in “Plastic and reconstructive surgery/PSEF CD journals” This study found that hydrogels supplemented with fractionated platelet-rich plasma recruited more dermal-derived stem cells and accelerated healing, leading to hair growth and skin regeneration in rats.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that STRIP1 and the STRIPAK complex play a key role in regulating F-actin and cell-cell junctions, which are essential for maintaining the epidermal barrier in mouse skin.
16 citations
,
December 2016 in “Molecular Medicine Reports” This study found that platelet-rich plasma may influence the proliferation of human hair dermal papilla cells by affecting gene expression related to the cell cycle.
3 citations
,
May 2020 in “Actas Dermo-Sifiliográficas” In this study, platelet-rich plasma injections improved hair density by 19.17% in men with androgenetic alopecia over six months, although results varied by alopecia pattern.
8 citations
,
June 2001 in “Journal of Biological Chemistry” This study found that the truncated hHb1-DeltaN transcript in breast cancer cells is produced by a cryptic intron promoter and responds to DNA demethylation, potentially altering cancer cell adhesion.
6 citations
,
September 2018 in “International Journal of Molecular Sciences” This study found that intramuscular injections of a PRP-derivative in healthy beagle dogs did not result in statistically significant changes in lumbar muscle tissue or IGF-1 blood concentration, suggesting the treatment may be safe at therapeutic doses.
April 2018 in “D-Scholarship@Pitt (University of Pittsburgh)” This study found that keratin-75, discovered in enamel tissue, is secreted by ameloblasts using an unconventional pathway involving the ER-Golgi-Intermediate-Compartment and Golgi, differing from typical cytokeratin localization.
January 2015 in “Spectrum Research Repository (Concordia University)” This study confirmed that porcine platelet-rich plasma could commercially replace fetal bovine serum due to its higher growth factor levels and effectiveness as a hair growth promoter comparable to existing serum.