Can Plasma Rich in Growth Factors Be Safe for Parental Use? A Safety Study in the Canine Model

September 2018 in “ International Journal of Molecular Sciences ”

Elena Damiá, Déborah Chicharro, Mónica Rubio, José M. Carrillo, Joaquín J. Sopena, Belén Cuervo, Sergio López, J. M. Vilar

platelet-rich plasma insulin-like growth factor-1 PRP IGF-1

TLDR PRP derivatives are likely safe for therapeutic use without harmful effects.

The study evaluated the safety of plasma rich in growth factors (PRGF) for intramuscular use in 24 healthy Beagle dogs. Researchers found no significant changes in insulin-like growth factor-1 (IGF-1) serum concentrations or muscle size, indicating that PRGF injections did not have systemic or local anabolic effects. The study concluded that PRGF application was safe, as it did not increase IGF-1 levels or cause muscle hypertrophy, even with higher doses. The findings suggested that PRGF could be a safe treatment option without ergogenic or carcinogenic risks, although further research was needed to assess its safety in humans.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

2 / 2 results

research Platelet-Rich Plasma for the Treatment of Androgenic Alopecia: A Systematic Review

23 citations , June 2018 in “Facial Plastic Surgery”

Platelet-Rich Plasma (PRP) is a low-risk treatment for Androgenic Alopecia (AGA) that generally improves hair count or density, but more research is needed for optimization.

research Systematic Review of the Use of Platelet-Rich Plasma in Aesthetic Dermatology

113 citations , July 2015 in “Journal of Cosmetic Dermatology”

Platelet-rich plasma may help with hair growth and skin quality but more research is needed to confirm its effectiveness.

Related Community Posts Join

6 / 601 results

community 30-Min Dermatology Visit – Best Questions to Ask About Balding? ( 175$ )

in Treatment 6 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on finasteride, minoxidil, and other options like PRP and ketoconazole. It highlights the importance of asking specific questions during a dermatology visit to determine the cause of hair loss and appropriate treatments.

community So what’s really the deal with dutasteride hairline ruining claims?

in Finasteride/Dutasteride 72 upvotes 3 years ago

The potential effects of dutasteride on hair loss, with some users reporting it improved their hairline while others experienced worsened hair loss or shedding. Other treatments discussed include minoxidil and finasteride, as well as RU58841.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

nkrata in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Could low blood flow to the head cause an increased rate of thinning?

in Chat 28 upvotes 4 years ago

The user started using finasteride, minoxidil, and biotin for male pattern baldness (MPB) and is experiencing rapid thinning. They are questioning if low blood flow to the head could be contributing to their hair loss.

community Nice & pure PRP, 3 ml of this is going to the scalp.

in Research/Science 32 upvotes 3 years ago

The use of PRP to treat hair loss and its potential effectiveness when combined with 5 alpha reductase blockers such as Minoxidil or Finasteride.

community Alright boys, who’s willing to burn their scalp for science?

in Research/Science 765 upvotes 3 years ago

Researching the effects of scalp trauma on hair growth, with some users suggesting experimenting with a soldering iron or derma pen, and others bringing up studies that suggest this may be an effective treatment.

Similar Research

6 / 1000+ results

Platelet-Rich Plasma: Applications in Cosmetic Medicine and Surgery

research Advantages and Clinical Applications of Lyophilized Platelet-Rich Plasma in Various Disease Conditions: A Review

November 2021 in “International Journal for Research in Applied Science and Engineering Technology”

Lyophilized platelet-rich plasma is beneficial and effective for various medical treatments, including tissue regeneration and hair regrowth.

Review of Human Hair Follicle Biology: Dynamics of Niches and Stem Cell Regulation for Possible Therapeutic Hair Stimulation for Plastic Surgeons

research Review of Human Hair Follicle Biology: Dynamics of Niches and Stem Cell Regulation for Possible Therapeutic Hair Stimulation for Plastic Surgeons

22 citations , October 2018 in “Aesthetic Plastic Surgery”

Understanding hair follicle biology and stem cell control could lead to new hair loss treatments.