Transcription Regulation and Protein Subcellular Localization of the Truncated Basic Hair Keratin hHb1-ΔN in Human Breast Cancer Cells

    Anne Boulay, Catherine H. Régnier, Patrick Anglard … Marie–Christine Rio
    Studysummary This study found that the truncated hHb1-DeltaN transcript in breast cancer cells is produced by a cryptic intron promoter and responds to DNA demethylation, potentially altering cancer cell adhesion.
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    Research cited in this study 16

    1. Characterization of a 300 Kbp Region of Human DNA Containing the Type II Hair Keratin Gene Domain Journal of Investigative Dermatology · 2000
    2. Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation Development · 1999
    3. Identification of Novel Mutations in Basic Hair Keratins hHb1 and hHb6 in Monilethrix: Implications for Protein Structure and Clinical Phenotype Journal of Investigative Dermatology · 1999
    4. The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16 ˜The œjournal of cell biology/˜The œJournal of cell biology · 1999
    5. Expression of a Truncated Form of hHb1 Hair Keratin in Human Breast Carcinomas British Journal of Cancer · 1998
    6. Characterization of a 190-Kilobase Pair Domain of Human Type I Hair Keratin Genes Journal of biological chemistry/˜The œJournal of biological chemistry · 1998
    7. Directed Expression of Keratin 16 to the Progenitor Basal Cells of Transgenic Mouse Skin Delays Skin Maturation The Journal of Cell Biology · 1998
    8. Characterization and Chromosomal Localization of Human Hair-Specific Keratin Genes and Comparative Expression During the Hair Growth Cycle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    9. A New Mutation in the Type II Hair Cortex Keratin hHb1 Involved in the Inherited Hair Disorder Monilethrix Human Genetics · 1997
    10. Mutations in the Hair Cortex Keratin HHB6 Cause the Inherited Hair Disease Monilethrix Nature Genetics · 1997
    11. Expression Pattern of Human Hair Keratin Basic 1 (hHbl) in Hair Follicle and Pilomatricoma Experimental Dermatology · 1997
    12. Sequence Data and Chromosomal Localization of Human Type I and Type II Hair Keratin Genes Experimental Cell Research · 1995
    13. Increased Expression of Keratin 16 Causes Anomalies in Cytoarchitecture and Keratinization in Transgenic Mouse Skin The Journal of Cell Biology · 1994
    14. Organization and Expression of Hair Follicle Genes ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993
    15. Organization and Expression of Hair Follicle Genes ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993
    16. Transient Expression of Mouse Hair Keratins in Transfected HeLa Cells: Interactions Between Hard and Soft Keratins Journal of Investigative Dermatology · 1991

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