Expression of a Truncated Form of hHb1 Hair Keratin in Human Breast Carcinomas

December 1998 in “ British Journal of Cancer ”

Catherine H. Régnier, Anne Boulay, PH Asch, Corinne Wendling, M-P Chenard, Catherine Tomasetto, MC Rio

Studysummary This study found that breast carcinomas ectopically express a truncated form of hHb1 mRNA, which is associated with epithelial cell transformation. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated the expression of a truncated form of hHb1 hair keratin in human breast carcinomas. It was found that breast carcinomas ectopically expressed a 5'-truncated mRNA of hHb1, which was restricted to malignant epithelial cells. The in vitro study suggested that this truncated mRNA could be translated, indicating a potential role in epithelial cell transformation. The hHb1 gene is located in a chromosome region (12q11-q13) known for breakpoints in solid tumors, suggesting it might be a target for genetic alterations in cancer.

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48 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

This article reviews the genetic and protein interactions involved in hair growth, highlighting regulatory sequences, expression patterns, and potential genetic modifications, but presents no new experimental findings.

research Hair Follicle Differentiation: Expression, Structure, and Evolutionary Conservation of the Hair Type II Keratin Intermediate Filament Gene Family

65 citations , February 1992 in “Development”

This study characterizes a type II keratin intermediate filament gene family involved in early sheep follicle differentiation, detailing gene expression patterns and sequences in hair cortical cells.

research Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues: Human and Bovine Hair Follicles

248 citations , April 1988 in “Differentiation”

In this study, researchers observed that trichocytic and epithelial cytokeratins have distinct expression patterns within various human and bovine hair follicle cells, contributing to understanding hair follicle development and growth.