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Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

Different species use the same genes for tooth regeneration.

Melatonin helps goat hair stem cells grow and maintain their ability to become different cell types.

Hedgehog signaling in certain cells is crucial for hair growth during wound healing.

3D cell cultures are better for testing hair growth treatments than 2D cultures.

Dermal papilla cells can help regrow hair and are promising for hair loss treatments.

The 2015 Hair Research Congress concluded that stem cells, maraviroc, and simvastatin could potentially treat Alopecia Areata, topical minoxidil, finasteride, and steroids could treat Frontal Fibrosing Alopecia, and PTGDR2 antagonists could also treat alopecia. They also found that low-level light therapy could help with hair loss, a robotic device could assist in hair extraction, and nutrition could aid hair growth. They suggested that Alopecia Areata is an inflammatory disorder, not a single disease, indicating a need for personalized treatments.

GLI2 increases follistatin production in human skin cells.

Chemokine signaling is important for hair development.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

Improved understanding of stem cell mechanisms can enhance skin tissue engineering.

Smad-4 and Smad-7 are key in hair follicle development, with other Smads being less important.

The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.

MOF controls skin development by regulating genes for mitochondria and cilia.

MicroRNA-214 is important for skin and hair growth because it affects the Wnt pathway.

miR-218-5p helps skin and hair growth by targeting SFRP2 and activating a specific signaling pathway.

Bioactive molecules show promise for improving skin repair and regeneration by overcoming current challenges with further research.

WNT10B is linked to cancer development and affects survival and disease progression in various cancers.

Dermal EZH2 controls skin cell development and hair growth in mice.

Ezh2 controls skin development by balancing signals for dermal and epidermal growth.

Dermal EZH2 controls skin cell growth and differentiation in mice.

The study concludes that the EDA2R gene is activated by p53 during chemotherapy but is not necessary for chemotherapy-induced hair loss.

Certain transcription factors are key in controlling skin stem cell behavior and could impact future treatments for skin repair and hair loss.

The document concludes that dermal papilla cells are key for hair growth and could be used in new hair loss treatments.

Genetic mutations can cause hair growth disorders by affecting key genes and signaling pathways.

Mechanical forces are crucial for shaping cells and forming tissues during development.

Sweat gland development involves two unique skin cell programs and a temporary skin environment.

Msx and Dlx genes are crucial for development, controlling cell behaviors like growth and differentiation through their roles as gene regulators.

miR-22, a type of microRNA, controls hair growth and its overproduction can cause hair loss, while its absence can speed up hair growth.

Removing a specific gene in certain skin cells causes hair loss on the body by disrupting normal hair development.